Dual Ti-Ru Catalysis in the Direct Radical Haloalkylation of N-Acyl Oxazolidinones

被引：65

作者：

Gu, Zhenhua ^{[1
]}

Herrmann, Aaron T. ^{[1
]}

Zakarian, Armen ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 31期

基金：

美国国家卫生研究院;

关键词：

haloalkylation; homogeneous catalysis; radicals; tautomerism; titanium enolates; VALENCE TAUTOMERISM; RUCL(CP-ASTERISK)(PPH3)(2); AUXILIARY;

D O I：

10.1002/anie.201101364

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Waste not, want not: A mechanistic study of the ruthenium-catalyzed haloalkylation of titanium enolates led to the development of a process that is catalytic in both metals: titanium and ruthenium (see scheme; Bn=benzyl, PMP=1,2,2,6,6-pentamethylpiperidine). Catalytic turnover was observed in the formation of the titanium enolates from N-acyl oxazolidinones, and insight was gained into the inhibitory effect of the amine base. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7136 / 7139

页数：4