Atezolizumab (A), cobimetinib (C), and vemurafenib (V) in patients (pts) with BRAFV600 mutation-positive melanoma with central nervous system (CNS) metastases (mets): Primary results from phase 2 Tricotel study.

被引:0
作者
Dummer, Reinhard
Queirolo, Paola
Guijarro, Ana Maria Abajo
Hu, Youyou
Wang, Dao
Azevedo, Sergio Jobim
Robert, Caroline
Ascierto, Paolo Antonio
Chiarion-Sileni, Vanna
Pronzato, Paolo
Spagnolo, Francesco
Mujika, Karmele
Liszkay, Gabriella
Merino, Luis De la Cruz
Tawbi, Hussein A.
机构
[1] Univ Hosp Zurich, Skin Canc Ctr, Zurich, Switzerland
[2] IRCCS, Ist Europeo Oncol, Milan, Italy
[3] F Hoffmann Roche Ltd, Basel, Switzerland
[4] Hosp Clinicas Porto Alegre, Unidade Pesquisa Clin Oncol, Porto Alegre, RS, Brazil
[5] Gustave Roussy, Villejuif Paris, France
[6] Univ Paris Saclay, Villejuif Paris, France
[7] Ist Nazl Tumori IRCCS Fdn G Pascale, Naples, Italy
[8] IRCCS, Ist Oncol Veneto IOV, Padua, Italy
[9] IRCCS Osped, Policlin San Martino, Genoa, Italy
[10] Onkol Hosp, Donostia San Sebastian, Spain
[11] Orszagos Onkol Int, Budapest, Hungary
[12] Hosp Univ Virgen Macarena, Seville, Spain
[13] Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX USA
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R73 [肿瘤学];
学科分类号
100214 ;
摘要
9515
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页数:1
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[21]   Effects of baseline lactate dehydrogenase (LDH), interferon gamma (IFN-g) expression, and tumor mutational burden (TMB) on treatment response to first-line atezolizumab (A) plus vemurafenib (V) and cobimetinib (C) in BRAFV600 mutation-positive advanced melanoma. [J].
Robert, Caroline ;
Lewis, Karl D. ;
Ascierto, Paolo Antonio ;
Munhoz, Rodrigo Ramella ;
Liszkay, Gabriella ;
de la Cruz-Merino, Luis ;
Olah, Judit ;
Queirolo, Paola ;
Mackiewicz, Jacek ;
Caro, Ivor ;
Shah, Kalpit ;
Forbes, Harper ;
Li, Haocheng ;
Hertig, Christian ;
Yan, Yibing ;
Mckenna, Edward Francis ;
Gutzmer, Ralf ;
McArthur, Grant A. .
JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
[22]   Atezolizumab, vemurafenib, and cobimetinib as first-line treatment for unresectable advanced BRAFV600 mutation-positive melanoma (IMspire150): primary analysis of the randomised, double-blind, placebo-controlled, phase 3 trial (vol 395, pg 1835, 2020) [J].
Gutzmer, R. ;
Stroyakovskiy, D. ;
Gogas, H. ;
Robert, Caroline ;
Lewis, Karl ;
Protsenko, Svetlana ;
Pereira, Rodrigo P. ;
Eigentler, Thomas ;
Rutkowski, Piotr ;
Demidov, Lev ;
Manikhas, Georgy Moiseevich ;
Yan, Yibing ;
Huang, Kuan-Chieh ;
Uyei, Anne ;
McNally, Virginia ;
McArthur, Grant A. ;
Ascierto, Paolo A. .
LANCET, 2020, 396 (10249) :466-466
[23]   Combination treatment with cobimetinib (C) and atezolizumab (A) vs pembrolizumab (P) in previously untreated patients (pts) with BRAFV600 wild type (wt) advanced melanoma: Primary analysis from the phase III IMspire170 trial [J].
Arance, A. M. ;
Gogas, H. ;
Dreno, B. ;
Flaherty, K. T. ;
Demidov, L. ;
Stroyakovskiy, D. ;
Eroglu, Z. ;
Ferrucci, P. F. ;
Pigozzo, J. ;
Rutkowski, P. ;
Mackiewicz, J. ;
Rooney, I. ;
Voulgari, A. ;
Troutman, S. ;
Pitcher, B. ;
Yan, Y. ;
Larkin, J. M. G. .
ANNALS OF ONCOLOGY, 2019, 30 :906-906
[24]   coBRIM: a phase 3, double-blind, placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAFV600 mutation–positive patients with unresectable locally advanced or metastatic melanoma (NCT01689519) [J].
Paolo A Ascierto ;
Grant A. McArthur ;
Brigitte Dréno ;
James Larkin ;
Gabriella Liszkay ;
Michele Maio ;
Mario Mandala ;
Lev Demidov ;
Daniil Stroyakovskiy ;
Luc Thomas ;
Luis de la Cruz-Merino ;
Victoria Atkinson ;
Caroline Dutriaux ;
Claus Garbe ;
Ilsung Chang ;
Stephen P. Hack ;
Antoni Ribas .
Journal of Translational Medicine, 13 (Suppl 1)
[25]   TRILOGY/IMspire150: A phase 3, double-blinded, randomized study of atezolizumab (A) plus cobimetinib (C) combined with vemurafenib (V) vs. placebo plus C combined with v in previously untreated BRAFV600 mutation-positive patients with locally advanced or metastatic melanoma (NCT02908672/EudraCT 2016-002482-54) [J].
Ascierto, P. ;
Lewis, K. ;
McArthur, G. ;
Rooney, I. ;
McNally, V. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017, 31 :46-47
[26]   The role of triple therapy and therapy sequence in treatment of BRAF-mutant metastatic melanoma. Response to overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, randomised, phase 3 study [J].
Dummer, Reinhard ;
Welti, Michele ;
Ramelyte, Egle .
JOURNAL OF TRANSLATIONAL MEDICINE, 2023, 21 (01)
[27]   The role of triple therapy and therapy sequence in treatment of BRAF-mutant metastatic melanoma. Response to overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, randomised, phase 3 study [J].
Reinhard Dummer ;
Michèle Welti ;
Egle Ramelyte .
Journal of Translational Medicine, 21
[28]   Phase 1 trial of MEK1 inhibitor E6201 plus dabrafenib in patients (pts) with BRAF V600-mutated metastatic melanoma (MM) with central nervous system (CNS) metastases (mets) [J].
Seetharam, Mahesh ;
Dronca, Roxana ;
Dudek, Arkadiusz Z. ;
Nelson, Garth ;
Block, Matthew ;
Starling, Skylar ;
Baskin, Amber ;
Bradshaw, Renee ;
Nelson, Courtney ;
Andrews, Kylee ;
Birgin, Alisha ;
Watson, Cristina ;
Yan, Yiyi ;
Mahadevan, Daruka ;
Markovic, Svetomir ;
Myers, Tom ;
Paradiso, Linda ;
Babiker, Hani .
CANCER RESEARCH, 2024, 84 (07)
[29]   Open-label, multicentre safety study of vemurafenib in 3219 patients with BRAFV600 mutation-positive metastatic melanoma: 2-year follow-up data and long-term responders' analysis [J].
Blank, Christian U. ;
Larkin, James ;
Arance, Ana M. ;
Hauschild, Axel ;
Queirolo, Paola ;
Del Vecchio, Michele ;
Ascierto, Paolo A. ;
Krajsova, Ivana ;
Schachter, Jacob ;
Neyns, Bart ;
Garbe, Claus ;
Sileni, Vanna Chiarion ;
Mandala, Mario ;
Gogas, Helen ;
Espinosa, Enrique ;
Hospers, Geke A. P. ;
Miller, Wilson H., Jr. ;
Robson, Susan ;
Makrutzki, Martina ;
Antic, Vladan ;
Brown, Michael P. .
EUROPEAN JOURNAL OF CANCER, 2017, 79 :176-184
[30]   BREAK-MB: A phase II study assessing overall intracranial response rate (OIRR) to dabrafenib (GSK2118436) in patients (pts) with BRAF V600E/k mutation-positive melanoma with brain metastases (mets). [J].
Kirkwood, John M. ;
Long, Georgina V. ;
Trefzer, Uwe ;
Davies, Michael A. ;
Ascierto, Paolo Antonio ;
Chapman, Paul B. ;
Puzanov, Igor ;
Hauschild, Axel ;
Robert, Caroline ;
Kefford, Richard ;
Goodman, Vicki L. ;
Switzky, Julie C. ;
Swann, R. Suzanne ;
Martin, Anne-Marie ;
Guckert, Mary E. ;
Streit, Michael R. W. ;
Schadendorf, Dirk .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)