The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate

被引：44
作者：
Dinis, P
Charrua, A
Avelino, A
Nagy, I
Quintas, J
Ribau, U
Cruz, F
机构：
[1] Hosp Sao Joao, Dept Urol, P-4200319 Oporto, Portugal
[2] Fac Med Porto, Inst Histol & Embryol, Oporto, Portugal
[3] Univ Porto, IBMC, Oporto, Portugal
[4] Univ London Imperial Coll Sci & Technol, Fac Med, Dept Anaesthesthet & Intens Care, Chelsea & Westminster Hosp, London, England
来源：
EUROPEAN UROLOGY | 2005年 / 48卷 / 01期
关键词：
sensory fibers; prostate; vanilloid receptor; Chronic Pelvic Pain Syndrome;
D O I：
10.1016/j.eururo.2005.01.009
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: To determine the distribution of sensory fibers immunoreactive to the pain receptor TRPV1 in the human prostate. Methods: Eight prostates were harvested from cadaver transplant donors and immediately immersion fixed. Longitudinal and transverse 20 mu m sections were cut on a cryostat and inummoreacted with two anti-human TPRV1 antibodies. Results: TRPV1-immunoreactive nerve fibers were distributed throughout the prostatic urethral mucosa, verumontanum, ejaculatory ducts and periurethral prostatic acini. In the urethral mucosa, TRPV1-immunoreactive fibers penetrated the epithelial layer up to its surface. In the transitional and peripheral zones of the gland no TRPV1-immunoreactive nerve fibers were detected. Conclusions: The existence of a rich TRPV1 sensory innervation in the human prostate may open new therapeutic perspectives for the treatment of pain in patients with chronic prostatitis (Chronic Pelvic Pain Syndrome). (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：162 / 167
页数：6
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