Prevention of nickel-induced allergic contact reactions with pentoxifylline

被引:8
作者
Saricaoglu, H
Tunali, S
Bulbul, E
White, IR
Palali, Z
机构
[1] Uludag Univ, Fac Med, Dept Dermatol, Bursa, Turkey
[2] St Thomas Hosp, St Johns Inst Dermatol, London SE1 7EH, England
关键词
pentoxifylline; experimental nickel sensitization; guinea pigs; inhibition elicitation phase;
D O I
10.1111/j.1600-0536.1998.tb05917.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
In this study, we investigated the effect of pentoxifylline, an inhibitor of TNF-alpha, on the contact sensitivity response induced by nickel. For induction, open epicutaneous sensitization by NiSO4 . 6 H2O (25% aq.) solution was applied on the backs of 38 albino guinea pigs 5 days a week for 4 weeks. NaCl (0.9%) solution was applied epicutaneously to 10 albino-guinea pigs as a control group. 19 were sensitized by nickel and developed positive patch test reactions. Patch tests were repeated after 10 of the sensitized pigs were given pentoxifylline 20 mg/kg/day orally. At the end of this study, only 2 positive patch test reactions were observed in the pentoxifylline-treated group, while 7/9 of the untreated guinea pigs developed positive reactions. These results suggest that pentoxifylline inhibits the contact sensitivity response induced by nickel only during drug administration.
引用
收藏
页码:244 / 247
页数:4
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