Update on Geographic Atrophy in Age-Related Macular Degeneration

被引：24

作者：

Biarnes, Marc ^{[1
]}

Mones, Jordi ^{[1
]}

Alonso, Jordi ^{[2
]}

Arias, Luis ^{[3
]}

机构：

[1] Ctr Med Teknon, Inst Macula & Retina, Barcelona 08022, Spain

[2] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain

[3] Bellvitge Hosp, Barcelona, Spain

来源：

OPTOMETRY AND VISION SCIENCE | 2011年 / 88卷 / 07期

关键词：

age-related macular degeneration; geographic atrophy; epidemiology; imaging techniques; treatment; COMPLEMENT FACTOR-H; FUNDUS AUTOFLUORESCENCE PATTERNS; DISEASE PROGRESSION; VISUAL IMPAIRMENT; 10-YEAR INCIDENCE; NATURAL-HISTORY; JUNCTIONAL ZONE; RISK-FACTORS; DIETARY-FAT; GLOBAL DATA;

D O I：

10.1097/OPX.0b013e31821988c1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Age-related macular degeneration (AMD) is the main cause of legal blindness in older patients in developed countries, and geographic atrophy (GA) represents the advanced form of dry AMD. Although it accounts for one third of the cases of late AMD and is responsible for 20% of the cases of severe visual loss due to the disorder. GA currently lacks effective treatment, whereas antiangiogenic therapies have been shown to be successful in managing choroidal neovascularization, the other form of late AMD. Recent advances in GA epidemiology, etiology, genetics, and imaging techniques have renewed the interest in this entity, which is a cause of progressive visual loss even in treated patients with neovascular AMD. This knowledge has triggered many clinical trials targeting different molecules shown to be associated with the disease, and it is hoped that this research will translate into effective drugs for GA in the near future. (Optom Vis Sci 2011; 88: 881-889)

引用

页码：881 / 889

页数：9

共 80 条

[1]

*AG REL EYE DIS ST, LUT ZEAX OM 3 SUPPL

[2]

ALLIKMETS R, 2008, AM AC OPHTH M ATL GE

[3] Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration [J].

Bindewald, A ;

Schmitz-Valckenberg, S ;

Jorzik, JJ ;

Dolar-Szczasny, J ;

Sieber, H ;

Keilhauer, C ;

Weinberger, AWA ;

Dithmar, S ;

Pauleikhoff, D ;

Mansmann, U ;

Wolf, S ;

Holz, FG .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2005, 89 (07) :874-878

[4] Cataract surgery and the development or progression of age-related macular degeneration: A systematic review [J].

Bockelbrink, Angelina ;

Roll, Stephanie ;

Ruether, Klaus ;

Rasch, Andrej ;

Greiner, Wolfgang ;

Willich, Stefan N. .

SURVEY OF OPHTHALMOLOGY, 2008, 53 (04) :359-367

[5] Correlation between Spectral-Domain Optical Coherence Tomography and Fundus Autofluorescence at the Margins of Geographic Atrophy [J].

Brar, Manpreet ;

Kozak, Igor ;

Cheng, Lingyun ;

Bartsch, Dirk-Uwe G. ;

Yuson, Ritchie ;

Nigam, Nitin ;

Oster, Stephen F. ;

Mojana, Francesca ;

Freeman, William R. .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2009, 148 (03) :439-444

[6] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration [J].

Chen, Wei ;

Stambolian, Dwight ;

Edwards, Albert O. ;

Branham, Kari E. ;

Othman, Mohammad ;

Jakobsdottir, Johanna ;

Tosakulwong, Nirubol ;

Pericak-Vance, Margaret A. ;

Campochiaro, Peter A. ;

Klein, Michael L. ;

Tan, Perciliz L. ;

Conley, Yvette P. ;

Kanda, Atsuhiro ;

Kopplin, Laura ;

Li, Yanming ;

Augustaitis, Katherine J. ;

Karoukis, Athanasios J. ;

Scott, William K. ;

Agarwal, Anita ;

Kovach, Jaclyn L. ;

Schwartz, Stephen G. ;

Postel, Eric A. ;

Brooks, Matthew ;

Baratz, Keith H. ;

Brown, William L. ;

Brucker, Alexander J. ;

Orlin, Anton ;

Brown, Gary ;

Ho, Allen ;

Regillo, Carl ;

Donoso, Larry ;

Tian, Lifeng ;

Kaderli, Brian ;

Hadley, Dexter ;

Hagstrom, Stephanie A. ;

Peachey, Neal S. ;

Klein, Ronald ;

Klein, Barbara E. K. ;

Gotoh, Norimoto ;

Yamashiro, Kenji ;

Ferris, Frederick, III ;

Fagerness, Jesen A. ;

Reynolds, Robyn ;

Farrer, Lindsay A. ;

Kim, Ivana K. ;

Miller, Joan W. ;

Corton, Marta ;

Carracedo, Angel ;

Sanchez-Salorio, Manuel ;

Pugh, Elizabeth W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (16) :7401-7406

[7] Dietary ω-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration -: A systematic review and meta-analysis [J].

Chong, Elaine W-T. ;

Kreis, Andreas J. ;

Wong, Tien Y. ;

Simpson, Julie A. ;

Guymer, Robyn H. .

ARCHIVES OF OPHTHALMOLOGY, 2008, 126 (06) :826-833

[8]

DELORI FC, 1995, INVEST OPHTH VIS SCI, V36, P718

[9] The role of inflammation in the pathogenesis of age-related macular degeneration [J].

Donoso, LA ;

Kim, D ;

Frost, A ;

Callahan, A ;

Hageman, G .

SURVEY OF OPHTHALMOLOGY, 2006, 51 (02) :137-152

[10] Modelling the natural history of geographic atrophy in patients with age-related macular degeneration [J].

Dreyhaupt, J ;

Mansmann, U ;

Pritsch, M ;

Dolar-Szczasny, J ;

Bindewald, A ;

Holz, FG .

OPHTHALMIC EPIDEMIOLOGY, 2005, 12 (06) :353-362

← 1 2 3 4 5 6 7 8 →