Carrier protein substrates in cytochrome P450-catalysed oxidation

被引：21

作者：

Cryle, Max J. ^{[1
]}

机构：

[1] Max Planck Inst Med Res, D-69120 Heidelberg, Germany

来源：

METALLOMICS | 2011年 / 3卷 / 04期

关键词：

PHENOL COUPLING REACTION; GLYCOPEPTIDE ANTIBIOTICS; BETA-HYDROXYTYROSINE; STRUCTURAL-CHARACTERIZATION; BACILLUS-SUBTILIS; CRYSTAL-STRUCTURE; LAURIC ACID; AMINO-ACID; VANCOMYCIN; BIOSYNTHESIS;

D O I：

10.1039/c0mt00081g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enzymes of the cytochrome P450 superfamily can catalyse many types of oxidative transformations of a diverse substrate range. This review summarises recent work on an subset of P450s that accept their substrates in carrier protein-bound form. These examples show how the oxidative power and precision that P450s bring to natural products biosynthesis can be coupled with the advantages of using a carrier protein as a scaffold for oxidation.

引用

页码：323 / 326

页数：4

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