Protective effect of irisin against Alzheimer's disease

被引：22
作者：
Chen, Kang [1 ,2 ]
Wang, Kun [2 ]
Wang, Tianhui [1 ,2 ]
机构：
[1] Tianjin Univ Sport, Tianjin Key Lab Exercise Physiol & Sports Med, Tianjin, Peoples R China
[2] Acad Mil Med Sci, Acad Mil Sci, Inst Environm & Operat Med, Tianjin, Peoples R China
来源：
FRONTIERS IN PSYCHIATRY | 2022年 / 13卷
关键词：
irisin; Alzheimer's disease; BDNF; neuroprotection; neuroinflammation; PHYSICAL-EXERCISE; HORMONE IRISIN; INJURY; FNDC5/IRISIN; EXPRESSION; NSAID; RISK; BDNF;
D O I：
10.3389/fpsyt.2022.967683
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Despite being one of the greatest global challenges for health and social care in the 21st century, Alzheimer's disease (AD) lacks specific medicine. Irisin, an exercise-generated muscle factor, emerges as a potential hormone for AD prevention and treatment because of its role in promoting the browning of white adipose tissue, accelerating energy expenditure, regulating energy metabolism, and improving insulin resistance. The study reviews classic hallmarks of AD and irisin's physiology before discussing the possible mechanism by which irisin protects against AD in terms of its effects related to molecular biology and cellular biology. Results reveal that irisin sharpens learning memory by inducing the production of brain-derived neurotrophic factor (BDNF), lowers the production of inflammatory factors, protects neurology through astrocytes, and ameliorates AD symptoms by improving insulin resistance. The review aims to facilitate future experimental studies and clinical applications of irisin in preventing and treating AD.
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页数：8
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共 61 条
[1]   Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia [J].
Agrawal, Ishan ;
Jha, Sushmita .
FRONTIERS IN AGING NEUROSCIENCE, 2020, 12
[2]   The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease [J].
Amidfar, Meysam ;
Oliveira, Jade de ;
Kucharska, Ewa ;
Budni, Josiane ;
Kim, Yong-Ku .
LIFE SCIENCES, 2020, 257
[3]   Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer's disease risk [J].
Baranowski, Bradley J. ;
Marko, Daniel M. ;
Fenech, Rachel K. ;
Yang, Alex J. T. ;
MacPherson, Rebecca E. K. .
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2020, 45 (10) :1055-1065
[4]   A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward [J].
Belloy, Michael E. ;
Napolioni, Valerio ;
Greicius, Michael D. .
NEURON, 2019, 101 (05) :820-838
[5]   A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis [J].
Bostroem, Pontus ;
Wu, Jun ;
Jedrychowski, Mark P. ;
Korde, Anisha ;
Ye, Li ;
Lo, James C. ;
Rasbach, Kyle A. ;
Bostroem, Elisabeth Almer ;
Choi, Jang Hyun ;
Long, Jonathan Z. ;
Kajimura, Shingo ;
Zingaretti, Maria Cristina ;
Vind, Birgitte F. ;
Tu, Hua ;
Cinti, Saverio ;
Hojlund, Kurt ;
Gygi, Steven P. ;
Spiegelman, Bruce M. .
NATURE, 2012, 481 (7382) :463-U72
[6]   The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease [J].
Budni, Josiane ;
Bellettini-Santos, Tatiani ;
Mina, Francielle ;
Garcez, Michelle Lima ;
Zugno, Alexandra Ioppi .
AGING AND DISEASE, 2015, 6 (05) :331-341
[7]   Tau-targeting therapies for Alzheimer disease [J].
Congdon, Erin E. ;
Sigurdsson, Einar M. .
NATURE REVIEWS NEUROLOGY, 2018, 14 (07) :399-415
[8]   Irisin and BDNF serum levels and behavioral disturbances in Alzheimer's disease [J].
Conti, Elisa ;
Grana, Denise ;
Stefanoni, Giovanni ;
Corsini, Alberto ;
Botta, Margherita ;
Magni, Paolo ;
Aliprandi, Angelo ;
Lunetta, Christian ;
Appollonio, Ildebrando ;
Ferrarese, Carlo ;
Tremolizzo, Lucio .
NEUROLOGICAL SCIENCES, 2019, 40 (06) :1145-1150
[9]   Exercise Intervention Associated with Cognitive Improvement in Alzheimer's Disease [J].
Cui, Meng Ying ;
Lin, Yang ;
Sheng, Ji Yao ;
Zhang, Xuewen ;
Cui, Ran Ji .
NEURAL PLASTICITY, 2018, 2018
[10]   Physical exercise in the prevention and treatment of Alzheimer's disease [J].
De la Rosa, Adrian ;
Olaso-Gonzalez, Gloria ;
Arc-Chagnaud, Coralie ;
Millan, Fernando ;
Salvador-Pascual, Andrea ;
Garcia-Lucerga, Consolacion ;
Blasco-Lafarga, Cristina ;
Garcia-Dominguez, Esther ;
Carretero, Aitor ;
Correas, Angela G. ;
Vina, Jose ;
Carmen Gomez-Cabrera, Mari .
JOURNAL OF SPORT AND HEALTH SCIENCE, 2020, 9 (05) :394-404
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