Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis

被引:11
作者
Eun, Sohyun [1 ]
Kim, Haemin [1 ]
Kim, Ha Yan [2 ]
Lee, Myeongjee [2 ]
Bae, Go Eun [3 ]
Kim, Heoungjin [1 ]
Koo, Chung Mo [1 ]
Kim, Moon Kyu [1 ]
Yoon, Seo Hee [1 ]
机构
[1] Yonsei Univ, Severance Childrens Hosp, Dept Pediat, Coll Med, Seoul, South Korea
[2] Yonsei Univ, Dept Biomed Syst Informat, Biostat Collaborat Unit, Coll Med, Seoul, South Korea
[3] Yonsei Univ, Dept Emergency Med, Coll Med, Seoul, South Korea
关键词
INTERNATIONAL CONSENSUS DEFINITIONS; IN-HOSPITAL MORTALITY; CLINICAL-PRACTICE PARAMETERS; NEONATAL SEPTIC SHOCK; PROGNOSTIC ACCURACY; SUSPECTED INFECTION; HEMODYNAMIC SUPPORT; AMERICAN-COLLEGE; SEPSIS; CRITERIA;
D O I
10.1038/s41598-021-01271-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We assessed the diagnostic accuracy of the age-adjusted quick Sequential Organ Failure Assessment score (qSOFA) for predicting mortality and disease severity in pediatric patients with suspected or confirmed infection. We conducted a systematic search of PubMed, EMBASE, the Cochrane Library, and Web of Science. Eleven studies with a total of 172,569 patients were included in the meta-analysis. The pooled sensitivity, specificity, and diagnostic odds ratio of the age-adjusted qSOFA for predicting mortality and disease severity were 0.69 (95% confidence interval [CI] 0.53-0.81), 0.71 (95% CI 0.36-0.91), and 6.57 (95% CI 4.46-9.67), respectively. The area under the summary receiver-operating characteristic curve was 0.733. The pooled sensitivity and specificity for predicting mortality were 0.73 (95% CI 0.66-0.79) and 0.63 (95% CI 0.21-0.92), respectively. The pooled sensitivity and specificity for predicting disease severity were 0.73 (95% CI 0.21-0.97) and 0.72 (95% CI 0.11-0.98), respectively. The performance of the age-adjusted qSOFA for predicting mortality and disease severity was better in emergency department patients than in intensive care unit patients. The age-adjusted qSOFA has moderate predictive power and can help in rapidly identifying at-risk children, but its utility may be limited by its insufficient sensitivity.
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页数:9
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