Tissue segmentation in Monte Carlo treatment planning: A simulation study using dual-energy CT images

被引:44
作者
Bazatova, Magdatena [1 ]
Carrier, Jean-Francois [2 ]
Beautieu, Luc [3 ,4 ,5 ]
Verhaegen, Frank [1 ]
机构
[1] McGill Univ, Ctr Hlth, Montreal Gen Hosp, Montreal, PQ H3G 1A4, Canada
[2] Hop Notre Dame CHUM, Dept Radiooncol, Montreal, PQ, Canada
[3] Univ Laval, Dept Radiooncol, Quebec City, PQ, Canada
[4] Univ Laval, Ctr Rech Cancerol, Quebec City, PQ, Canada
[5] Univ Laval, Dept Phys Genie Phys & Opt, Quebec City, PQ, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
dual-energy CT; Monte Carlo; tissue segmentation;
D O I
10.1016/j.radonc.2007.11.008
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Tissue segmentation is an important step in Monte Carlo (MC) dose calculation and is often done uncritically. A new approach to tissue segmentation using dual-energy CT images is studied in this work. Materials and methods: A simple MC model of a CT scanner was built and CT images of phantoms with ten tissue-equivalent cylinders were simulated using soft and hard X-ray spectra. The Z and rho(e) of the cylinders were extracted using a formalism based on a parameterization of the linear attenuation coefficient. Results: It was shown that in order to extract Z and rho(e) with a reasonable accuracy, hard X-ray beams have to be used for scanning. When an additional filtration of 9 mm of aluminium in the CT X-ray beam is used, beam hardening in high density materials is suppressed and the mean errors of the extraction of Z and rho(e) for 10 tissue-equivalent materials in a small tissue-equivalent phantom are 3.7% and 3.1%, respectively. Conclusions: MC simulations were used to show that the extraction of Z and rho(e) for a number of tissue-equivalent materials using dual-energy CT images is possible which improves tissue segmentation for Monte Carlo dose calculations, as demonstrated with a 250 kVp photon beam dose calculation. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:93 / 98
页数:6
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