Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial

被引：22

作者：

Baye, Estifanos ^{[1
]}

Ukropec, Jozef ^{[2
]}

de Courten, Maximilian P. J. ^{[3
]}

Vallova, Silvia ^{[4
]}

Krumpolec, Patrik ^{[2
]}

Kurdiova, Timea ^{[2
]}

Aldini, Giancarlo ^{[5
]}

Ukropcova, Barbara ^{[2
,4
]}

de Courten, Barbora ^{[1
]}

机构：

[1] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Melbourne, Vic, Australia

[2] Slovak Acad Sci, Inst Expt Endocrinol, Biomed Res Ctr, Bratislava, Slovakia

[3] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis, Melbourne, Vic, Australia

[4] Comenius Univ, Inst Pathol Physiol, Fac Med, Bratislava, Slovakia

[5] Univ Milan, Dept Pharmaceut Sci, Milan, Italy

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

LOW-DENSITY LIPOPROTEINS; INSULIN SENSITIVITY; GLUCOSE-METABOLISM; HDL LIPIDOME; RISK; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLCHOLINE; BIOSYNTHESIS; INDIVIDUALS; PROGRESSION;

D O I：

10.1038/s41598-017-17577-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Carnosine has been shown to reduce oxidation and glycation of low density lipoprotein hence improving dyslipidaemia in rodents. The effect of carnosine on human plasma lipidome has thus far not been investigated. We aimed to determine whether carnosine supplementation improves the plasma lipidome in overweight and obese individuals. Lipid analysis was performed by liquid chromatography mass spectrometry in 24 overweight and obese adults: 13 were randomly assigned to 2 g carnosine daily and 11 to placebo, and treated for 12 weeks. Carnosine supplementation maintained trihexosylceramide (0.01 +/- 0.19 vs -0.28 +/- 0.34 nmol/ml, p = 0.04), phosphatidylcholine (77 +/- 167 vs -81 +/- 196 nmol/ml, p = 0.01) and free cholesterol (20 +/- 80 vs -69 +/- 80 nmol/ml, p = 0.006) levels compared to placebo. Trihexosylceramide was inversely related with fasting insulin (r = -0.6, p = 0.002), insulin resistance (r = -0.6, p = 0.003), insulin secretion (r = -0.4, p = 0.05) and serum carnosinase 1 activity (r = -0.3, p = 0.05). Both phosphatidylcholine and free cholesterol did not correlate with any cardiometabolic parameters. Our data suggest that carnosine may have beneficial effects on the plasma lipidome. Future larger clinical trials are needed to confirm this.

引用

页数：7

共 48 条

[1] Different conformational forms of serum carnosinase detected by a newly developed sandwich ELISA for the measurements of carnosinase concentrations [J].