Current Knowledge and Future Perspectives on Mesenchymal Stem Cell-Derived Exosomes as a New Therapeutic Agent

被引：209

作者：

Joo, Hyeon Su ^{[1
]}

Suh, Ju Hun ^{[1
]}

Lee, Hyeon Ji ^{[1
]}

Bang, Eun Song ^{[1
]}

Lee, Jung Min ^{[1
]}

机构：

[1] Handong Global Univ, Sch Life Sci, Pohang 37554, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

mesenchymal stem cell; exosome; pre-conditioning; translational medicine; ISCHEMIA-REPERFUSION INJURY; EXTRACELLULAR VESICLES; REGENERATIVE MEDICINE; STROMAL CELLS; PROMOTE ANGIOGENESIS; FUNCTIONAL RECOVERY; RELEASE; DIFFERENTIATION; ACCUMULATION; CONTRIBUTES;

D O I：

10.3390/ijms21030727

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesenchymal stem cells (MSCs) are on the cusp of regenerative medicine due to their differentiation capacity, favorable culture conditions, ability to be manipulated in vitro, and strong immunomodulatory activity. Recent studies indicate that the pleiotropic effects of MSCs, especially their immunomodulatory potential, can be largely attributed to paracrine factors. Exosomes, vesicles that are 30-150 nanometers in diameter that function in cell-cell communication, are one of the key paracrine effectors. MSC-derived exosomes are enriched with therapeutic miRNAs, mRNAs, cytokines, lipids, and growth factors. Emerging evidences support the compelling possibility of using MSC-derived exosomes as a new form of therapy for treating several different kinds of disease such as heart, kidney, immune diseases, neural injuries, and neurodegenerative disease. This review provides a summary of current knowledge and discusses engineering of MSC-derived exosomes for their use in translational medicine.

引用

页数：22

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