Novel Characterization of Myeloid-Derived Suppressor Cells in Tumor Microenvironment

被引：23

作者：

Li, Yanan ^{[1
]}

He, Hongdan ^{[2
]}

Jihu, Ribu ^{[1
]}

Zhou, Junfu ^{[1
]}

Zeng, Rui ^{[1
]}

Yan, Hengxiu ^{[1
]}

机构：

[1] Southwest Minzu Univ, Immunotherapy Lab, Coll Pharmacol, Chengdu, Peoples R China

[2] Southwest Minzu Univ, Immunotherapy Lab, Tibet Plateau Res Inst, Chengdu, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

关键词：

tumor microenvironment; myeloid-derived suppressor cells; targeted therapy; multivariate effects; regulation; PREMETASTATIC NICHE FORMATION; ENDOTHELIAL GROWTH-FACTOR; REGULATORY T-CELLS; IMMUNE SUPPRESSION; IMMUNOSUPPRESSIVE FUNCTIONS; BONE-MARROW; TH17; CELLS; CANCER; INHIBITION; ACCUMULATION;

D O I：

10.3389/fcell.2021.698532

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells generated in various pathologic conditions, which have been known to be key components of the tumor microenvironment (TME) involving in tumor immune tolerance. So MDSCs have been extensively researched recently. As its name suggests, immunosuppression is the widely accepted function of MDSCs. Aside from suppressing antitumor immune responses, MDSCs in the TME also stimulate tumor angiogenesis and metastasis, thereby promoting tumor growth and development. Therefore, altering the recruitment, expansion, activation, and immunosuppression of MDSCs could partially restore antitumor immunity. So, this view focused on the favorable TME conditions that promote the immunosuppressive effects of MDSCs and contribute to targeted therapies with increased precision for MDSCs.</p>

引用

页数：15

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