Phase Ib Study of the Anti-TIM-3 Antibody MBG453 in Combination with Decitabine in Patients with High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

被引：70

作者：

Borate, Uma ^{[1
]}

Esteve, Jordi ^{[2
]}

Porkka, Kimmo ^{[3
]}

Knapper, Steve ^{[4
]}

Vey, Norbert ^{[5
]}

Scholl, Sebastian ^{[6
]}

Garcia-Manero, Guillermo ^{[7
]}

Wermke, Martin ^{[8
]}

Janssen, Jeroen ^{[9
]}

Traer, Elie ^{[10
]}

Chua, Chong Chyn ^{[11
]}

Narayan, Rupa ^{[12
]}

Tovar, Natalia ^{[2
]}

Kontro, Mika ^{[13
]}

Ottmann, Oliver ^{[14
]}

Sun, Haiying ^{[15
]}

Longmire, Tyler ^{[16
]}

Szpakowski, Sebastian ^{[16
]}

Liao, Serena ^{[16
]}

Patel, Anuradha ^{[17
]}

Rinne, Mikael L. ^{[16
]}

Brunner, Andrew ^{[18
]}

Wei, Andrew H. ^{[11
]}

机构：

[1] Oregon Hlth & Sci Univ, Knight Canc Inst, Div Hematol & Med Oncol, Portland, OR 97201 USA

[2] Hosp Clin Barcelona, Barcelona, Spain

[3] Univ Helsinki, Dept Hematol, Cent Hosp, Canc Ctr, Helsinki, Finland

[4] Cardiff Univ, Dept Heamatol, Cardiff, S Glam, Wales

[5] Inst Paoli Calmettes, Hematol Clin, Marseille, France

[6] Univ Hosp Jena, Jena, Germany

[7] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[8] Univ Hosp Dresden, Dresden, Germany

[9] Univ Amsterdam, VU Univ, Med Ctr, Amsterdam, Netherlands

[10] Oregon Hlth & Sci Univ, Div Hematol & Med Oncol, Portland, OR 97201 USA

[11] Alfred Hosp, Melbourne, Vic, Australia

[12] Massachusetts Gen Hosp, Boston, MA 02114 USA

[13] Helsinki Univ Hosp, Dept Hematol, Canc Ctr, Helsinki, Finland

[14] Cardiff Univ, Dept Haematol, Cardiff, S Glam, Wales

[15] Novartis Pharmaceut, E Hanover, NJ USA

[16] Novartis Inst BioMed Res, Cambridge, MA USA

[17] Novartis Pharmaceut, E Hanover, NJ USA

[18] Massachusetts Gen Hosp, Hematol Oncol, Boston, MA 02114 USA

来源：

BLOOD | 2019年 / 134卷

关键词：

D O I：

10.1182/blood-2019-128178

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

570

引用

页数：6