Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide

被引：123
|
作者：
Banmeyer, I [1 ]
Marchand, C [1 ]
Clippe, A [1 ]
Knoops, B [1 ]
机构：
[1] Univ Catholique Louvain, Cell Biol Lab, Inst Sci Vie, B-1348 Louvain, Belgium
来源：
FEBS LETTERS | 2005年 / 579卷 / 11期
关键词：
peroxiredoxin; thioredoxin peroxidase; antioxidant enzyme; mitochondria; peroxide;
D O I：
10.1016/j.febslet.2005.03.027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peroxiredoxin 5 is a thioredoxin peroxidase ubiquitously expressed in mammalian tissues. Peroxiredoxin 5 can be addressed intracellularly to mitochondria, peroxisomes, the cytosol and the nucleus. Here, we show that mitochondrial human peroxiredoxin 5 protects mitochondrial DNA (mtDNA) from oxidative attacks. In an acellular assay, recombinant peroxiredoxin 5 was shown to protect plasmid DNA from damages induced by metal-catalyzed generation of reactive oxygen species. In Chinese hamster ovary cells, overexpression of mitochondrial peroxiredoxin 5 significantly decreased mtDNA damages caused by exogenously added hydrogen peroxide. Altogether our results suggest that mitochondrial peroxiredoxin 5 may play an important role in mitochondrial genome stability. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2327 / 2333
页数：7
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