Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide

被引：123

作者：

Banmeyer, I ^{[1
]}

Marchand, C ^{[1
]}

Clippe, A ^{[1
]}

Knoops, B ^{[1
]}

机构：

[1] Univ Catholique Louvain, Cell Biol Lab, Inst Sci Vie, B-1348 Louvain, Belgium

来源：

FEBS LETTERS | 2005年 / 579卷 / 11期

关键词：

peroxiredoxin; thioredoxin peroxidase; antioxidant enzyme; mitochondria; peroxide;

D O I：

10.1016/j.febslet.2005.03.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxiredoxin 5 is a thioredoxin peroxidase ubiquitously expressed in mammalian tissues. Peroxiredoxin 5 can be addressed intracellularly to mitochondria, peroxisomes, the cytosol and the nucleus. Here, we show that mitochondrial human peroxiredoxin 5 protects mitochondrial DNA (mtDNA) from oxidative attacks. In an acellular assay, recombinant peroxiredoxin 5 was shown to protect plasmid DNA from damages induced by metal-catalyzed generation of reactive oxygen species. In Chinese hamster ovary cells, overexpression of mitochondrial peroxiredoxin 5 significantly decreased mtDNA damages caused by exogenously added hydrogen peroxide. Altogether our results suggest that mitochondrial peroxiredoxin 5 may play an important role in mitochondrial genome stability. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2327 / 2333

页数：7

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