A potential role for estrogen in cigarette smoke-induced microRNA alterations and lung cancer

被引：8

作者：

Cohen, Amit ^{[1
]}

Alberto Burgos-Aceves, Mario ^{[2
]}

Smith, Yoav

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Genom Data Anal Unit, Jerusalem, Israel

[2] Ctr Invest Biol Noroeste SC, Mar Bermejo 195, La Paz, Bcs, Mexico

来源：

TRANSLATIONAL LUNG CANCER RESEARCH | 2016年 / 5卷 / 03期

关键词：

Cigarette-smoke (CS); estrogen; microRNA (miRNA); lung cancer (LC); DOWN-REGULATION; BREAST-CANCER; PROGESTERONE-RECEPTORS; CELL-PROLIFERATION; PROTEOME PROFILES; TUMOR PROGRESSION; STEROID-RECEPTORS; SEX-HORMONES; EXPRESSION; ALPHA;

D O I：

10.21037/tlcr.2016.06.08

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Alteration in the expression of microRNAs (miRNAs) is associated with oncogenesis and cancer progression. In this review we aim to suggest that elevated levels of estrogens and their metabolites inside the lungs as a result of cigarette smoke exposure can cause widespread repression of miRNA and contribute to lung tumor development. Anti-estrogenic compounds, such as the components of cruciferous vegetables, can attenuate this effect and potentially reduce the risk of lung cancer (LC) among smokers.

引用

页码：322 / 330

页数：9

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