Endothelial cell apoptosis in angiogenesis and vessel regression

被引：117

作者：

Watson, Emma C. ^{[1
,2
,3
,4
]}

Grant, Zoe L. ^{[1
,2
]}

Coultas, Leigh ^{[1
,2
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Dev & Canc Div, 1G Royal Parade, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Med Biol, 1G Royal Parade, Parkville, Vic 3052, Australia

[3] Max Planck Inst Mol Biomed, Dept Tissue Morphogenesis, D-48149 Munster, Germany

[4] Univ Munster, Fac Med, D-48149 Munster, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2017年 / 74卷 / 24期

基金：

英国医学研究理事会;

关键词：

Vessel pruning; BCL2; Death receptors; Diabetes; Diabetic retinopathy; OXYGEN-INDUCED RETINOPATHY; NITRIC-OXIDE SYNTHASE; PROTEIN-KINASE-C; GROWTH-FACTOR; PUPILLARY MEMBRANE; TUMOR VASCULATURE; RETINAL-VESSELS; CYTOCHROME-C; BH3; DOMAINS; VE-CADHERIN;

D O I：

10.1007/s00018-017-2577-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood vessel regression is an essential process for ensuring blood vessel networks function at optimal efficiency and for matching blood supply to the metabolic needs of tissues as they change over time. Angiogenesis is the major mechanism by which new blood vessels are produced, but the vessel growth associated with angiogenesis must be complemented by remodeling and maturation events including the removal of redundant vessel segments and cells to fashion the newly forming vasculature into an efficient, hierarchical network. This review will summarize recent findings on the role that endothelial cell apoptosis plays in vascular remodeling during angiogenesis and in vessel regression more generally.

引用

页码：4387 / 4403

页数：17

共 169 条

[51] Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells [J].