Platelet factor 4 increases bone marrow B cell development and differentiation

被引：15

作者：

Field, David J. ^{[1
]}

Aggrey-Amable, Angela A. ^{[1
]}

Blick, Sara K. ^{[2
]}

Ture, Sara K. ^{[1
]}

Johanson, Andrew ^{[1
]}

Cameron, Scott J. ^{[1
]}

Roy, Sukanya ^{[1
]}

Morrell, Craig N. ^{[1
]}

机构：

[1] Univ Rochester, Aab Cardiovasc Res Inst, Med Ctr, Box CVRI,601 Elmwood Ave, Rochester, NY 14642 USA

[2] Rochester Inst Technol, Bridges Doctorate Deaf & Hard Hearing Students, Rochester, NY 14623 USA

来源：

IMMUNOLOGIC RESEARCH | 2017年 / 65卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Platelet Factor 4; B cell; Bone marrow; QUIESCENCE; CXCL4; STAT5; MICE;

D O I：

10.1007/s12026-017-8951-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Platelet factor 4 (PF4) is a megakaryocyte-/platelet-derived chemokine with diverse functions as a regulator of vascular and immune biology. PF4 has a central role in vessel injury responses, innate immune cell responses, and T-helper cell differentiation. We have now discovered that PF4 has a direct role in B cell differentiation in the bone marrow. Mice lacking PF4 (PF4(-/-) mice) had fewer developing B cells in the bone marrow beginning after the pre-pro-B cell stage of differentiation. In vitro, PF4 increased the differentiation of hematopoietic progenitors to B cell lineage cells, indicating that PF4 has a direct effect on B cell differentiation. STAT5 activation is essential in early B cell development and PF4 increased the phosphorylation of STAT5. Taken together, these data demonstrate that PF4 has an important role in increasing B cell differentiation in the bone marrow environment.

引用

页码：1089 / 1094

页数：6

共 17 条

[1] Interaction of PF4 (CXCL4) with the vasculature: A role in atherosclerosis and angiogenesis [J].

Aidoudi, Sallouha ;

Bikfalvi, Andreas .

THROMBOSIS AND HAEMOSTASIS, 2010, 104 (05) :941-948

[2] Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion [J].

Bruns, Ingmar ;

Lucas, Daniel ;

Pinho, Sandra ;

Ahmed, Jalal ;

Lambert, Michele P. ;

Kunisaki, Yuya ;

Scheiermann, Christoph ;

Schiff, Lauren ;

Poncz, Mortimer ;

Bergman, Aviv ;

Frenette, Paul S. .

NATURE MEDICINE, 2014, 20 (11) :1315-1320

[3] 4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4 [J].

Cheng, Suk Hang ;

Ng, Margaret H. L. ;

Lau, Kin Mang ;

Liu, Herman S. Y. ;

Chan, Joyce C. W. ;

Hui, Angela B. Y. ;

Lo, Kwok Wai ;

Jiang, Hua ;

Hou, Jian ;

Chu, Raymond W. ;

Wong, Wai Shan ;

Chan, Natalie P. H. ;

Ng, Ho Keung .

BLOOD, 2007, 109 (05) :2089-2099

[4] Stat5 is essential for early B cell development but not for B cell maturation and function [J].

Dai, Xuezhi ;

Chen, Yuhong ;

Di, Lie ;

Podd, Andrew ;

Li, Geqiang ;

Bunting, Kevin D. ;

Hennighausen, Lothar ;

Wen, Renren ;

Wang, Demin .

JOURNAL OF IMMUNOLOGY, 2007, 179 (02) :1068-1079

[5] Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin [J].

Eslin, DE ;

Zhang, CY ;

Samuels, KJ ;

Rauova, L ;

Zhai, L ;

Niewiarowski, S ;

Cines, DB ;

Poncz, M ;

Kowalska, MA .

BLOOD, 2004, 104 (10) :3173-3180

[6] Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice [J].

Forlow, SB ;

Schurr, JR ;

Kolls, JK ;

Bagby, GJ ;

Schwarzenberger, PO ;

Ley, K .

BLOOD, 2001, 98 (12) :3309-3314

[7] Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling [J].

Herzog, Sebastian ;

Reth, Michael ;

Jumaa, Hassan .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (03) :195-205

[8] THE ROLE OF PLATELET FACTOR 4 IN RADIATION-INDUCED THROMBOCYTOPENIA [J].

Lambert, Michele P. ;

Xiao, Liqing ;

Nguyen, Yvonne ;

Kowalska, M. Anna ;

Poncz, Mortimer .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 80 (05) :1533-1540

[9] Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes [J].

Lambert, Michele P. ;

Wang, Yuhuan ;

Bdeir, Khalil H. ;

Nguyen, Yvonne ;

Kowalska, M. Anna ;

Poncz, Mortimer .

BLOOD, 2009, 114 (11) :2290-2298

[10]

Liang P, 2012, HAEMATOLOGICA

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