Alkaline phosphatase-triggered self-assembly of near-infrared nanoparticles for the enhanced photoacoustic imaging of tumors

被引：5

作者：

Wu, Chengfan ^{[1
]}

Zhang, Rui ^{[2
]}

Du, Wei ^{[1
]}

Cheng, Liang ^{[2
]}

Liang, Gaolin ^{[1
,3
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei Natl Lab Phys Sci Microscale, Hefei, AH, Peoples R China

[2] Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou, JS, Peoples R China

[3] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing, JS, Peoples R China

来源：

PHOTOACOUSTIC PROBES FOR IN VIVO IMAGING | 2021年 / 657卷

关键词：

TOMOGRAPHY; AGENTS;

D O I：

10.1016/bs.mie.2021.06.028

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

In this chapter, we discuss the need for the development of enzyme-activatable probes in the field of tumor-targeted photoacoustic (PA) imaging, then we give a brief description of the innovation of designing alkaline phosphatase (ALP)-activatable probes for PA imaging. After that, we provide detailed protocols for the syntheses and characterizations of a near-infrared photoacoustic imaging probe, 1P, developed in our research group. With this tool, 1P could form nanoparticles 1-NPs under the catalysis of ALP and thus could be used to enhance PA imaging both in vitro and in vivo.

引用

页码：111 / 144

页数：34

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