Alkaline phosphatase-triggered self-assembly of near-infrared nanoparticles for the enhanced photoacoustic imaging of tumors

被引：5
|
作者：
Wu, Chengfan [1 ]
Zhang, Rui [2 ]
Du, Wei [1 ]
Cheng, Liang [2 ]
Liang, Gaolin [1 ,3 ]
机构：
[1] Univ Sci & Technol China, Dept Chem, Hefei Natl Lab Phys Sci Microscale, Hefei, AH, Peoples R China
[2] Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou, JS, Peoples R China
[3] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing, JS, Peoples R China
来源：
PHOTOACOUSTIC PROBES FOR IN VIVO IMAGING | 2021年 / 657卷
关键词：
TOMOGRAPHY; AGENTS;
D O I：
10.1016/bs.mie.2021.06.028
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
In this chapter, we discuss the need for the development of enzyme-activatable probes in the field of tumor-targeted photoacoustic (PA) imaging, then we give a brief description of the innovation of designing alkaline phosphatase (ALP)-activatable probes for PA imaging. After that, we provide detailed protocols for the syntheses and characterizations of a near-infrared photoacoustic imaging probe, 1P, developed in our research group. With this tool, 1P could form nanoparticles 1-NPs under the catalysis of ALP and thus could be used to enhance PA imaging both in vitro and in vivo.
引用
收藏
页码：111 / 144
页数：34
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