Synthesis of Stable σ-Adducts by Arylation of Quinazoline

被引：1
作者：
Azev, Yu. A. [1 ]
Koptyaeva, O. S. [1 ]
Seliverstova, E. A. [1 ]
Ivoilova, A. V. [1 ]
Pospelova, T. A. [1 ]
机构：
[1] Yeltsin Ural Fed Univ, Ekaterinburg, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 12期
基金：
俄罗斯基础研究基金会;
关键词：
quinazoline; C-nucleophiles; C-C-bond formation; DERIVATIVES;
D O I：
10.1134/S1070363219120089
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reactions of quinazoline with 1,3,5-trimethoxybenzene, 3- and 4-methylbenzene-1,2-diamines, and 1-(4-methoxybenzylidene)-2-phenylhydrazine on heating in the presence of trifluoroacetic acid afforded the corresponding stable C-C sigma-adducts.
引用
收藏
页码：2374 / 2377
页数：4
相关论文
共 15 条
  • [1] Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs
    Al-Obaid, Abdulrahman M.
    Abdel-Hamide, Sami G.
    El-Kashef, Hassan A.
    Abdel-Aziz, Alaa A. -M.
    El-Azab, Adel S.
    Al-Khamees, Hamad A.
    El-Subbagh, Hussein I.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (06) : 2379 - 2391
  • [2] !Molecular docking and biological evaluation of some thioxoquinazolin-4(3H)-one derivatives as anticancer, antioxidant and anticonvulsant agents
    Al-Shamary, Danah S.
    Al-Alshaikh, Monirah A.
    Kheder, Nabila Abdelshafy
    Mabkhot, Yahia Nasser
    Badshah, Syed Lal
    [J]. CHEMISTRY CENTRAL JOURNAL, 2017, 11
  • [3] Synthesis, analgesic and anti-inflammatory evaluation of some new 3H-quinazolin-4-one derivatives
    Alafeefy, Ahmed M.
    Kadi, Adnan A.
    El-Azab, Adel S.
    Abdel-Hamide, Sami G.
    Daba, Mohamad-Hesham Y.
    [J]. ARCHIV DER PHARMAZIE, 2008, 341 (06) : 377 - 385
  • [4] Aniszewski T., 2015, ALKALOIDS, V2nd ed., P195, DOI [10.1016/B978-0-444-59433-4.00003-1, DOI 10.1016/B978-0-444-59433-4.00003-1]
  • [5] Specific features of the reactions of quinazoline and its 4-hydroxy and 4-chloro substituted derivatives with C-nucleophiles
    Azev, Yuri A.
    Shorshnev, Sergey V.
    Golomolzin, Boris V.
    [J]. TETRAHEDRON LETTERS, 2009, 50 (24) : 2899 - 2903
  • [6] CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones
    Jatav, Varsha
    Mishra, Pradeep
    Kashaw, Sushil
    Stables, J. P.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (09) : 1945 - 1954
  • [7] Original quinazoline derivatives displaying antiplasmodial properties
    Kabri, Youssef
    Azas, Nadine
    Dumetre, Aurelien
    Hutter, Sebastien
    Laget, Michele
    Verhaeghe, Pierre
    Gellis, Armand
    Vanelle, Patrice
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (02) : 616 - 622
  • [8] Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea
    Kashaw, Sushil K.
    Kashaw, Varsha
    Mishra, Pradeep
    Jain, N. K.
    Stables, J. P.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (11) : 4335 - 4343
  • [9] Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification
    Khan, Imtiaz
    Zaib, Sumera
    Batool, Sadaf
    Abbas, Naeem
    Ashraf, Zaman
    Iqbal, Jamshed
    Saeed, Aamer
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (11) : 2361 - 2381
  • [10] Matern AI, 2007, THESIS
12