Canine distemper virus DNA vaccination of mink can overcome interference by maternal antibodies

被引：15

作者：

Jensen, Trine Hammer ^{[1
,2
]}

Nielsen, Line ^{[1
]}

Aasted, Bent ^{[1
]}

Pertoldi, Cino ^{[2
]}

Blixenkrone-Moller, Merete ^{[3
]}

机构：

[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet Dis Biol, DK-1870 Frederiksberg C, Denmark

[2] Aalborg Univ, Fac Sci & Engn, Dept Chem & Biosci, Aalborg Zoo, DK-9220 Aalborg, Denmark

[3] Univ Copenhagen, Fac Hlth & Med Sci, Dept Int Hlth Immunol & Microbiol, DK-2200 Copenhagen N, Denmark

来源：

VACCINE | 2015年 / 33卷 / 11期

关键词：

Canine distemper virus; Morbillivirus; Neonatal; Mink; Maternal antibodies; DNA vaccination; PROTEINS PROTECTS JUVENILE; INFANT RHESUS MACAQUES; MEASLES-VIRUS; WILD-TYPE; ROBUST PROTECTION; IMMUNE-RESPONSES; HEMAGGLUTININ; FUSION; INFECTION; VACCINES;

D O I：

10.1016/j.vaccine.2015.01.029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Canine distemper virus (CDV) is highly contagious and can cause severe disease against which conventional live vaccines are ineffective in the presence of maternal antibodies. Vaccination in the presences of maternal antibodies was challenged by vaccination of 5 days old and 3 weeks old mink kits with CDV DNA vaccines. Virus neutralising (VN) antibody responses were induced in mink kits vaccinated with a plasmid encoding the haemaglutinin protein (H) of CDV (n = 5, pCDV-H) or a combination of the H, fusion (F) and nucleoprotein (N) of CDV (n = 5, pCDV-HFN). These DNA vaccinated kits were protected against virulent experimental infection with field strains of CDV. The pCDV-H was more efficient in inducing protective immunity in the presence of maternal antibodies compared to the pCDV-HFN. The results shim, that DNA vaccination with the pCDV-H or pCDV-HFN (n = 4) only given once at 5 days of age induces virus specific immune response in neonatal mink and protection against virulent CDV exposure later in life. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1375 / 1381

页数：7

共 32 条

[1]

APPEL MJG, 1969, AM J VET RES, V30, P1167

[2]

Blixenkrone-Moller M, 1991, J Vet Diagn Invest, V3, P3

[3]

BLIXENKRONEMOLLER M, 1989, AM J VET RES, V50, P1616

[4] STUDIES ON MANIFESTATIONS OF CANINE-DISTEMPER VIRUS-INFECTION IN AN URBAN DOG-POPULATION [J].

BLIXENKRONEMOLLER, M ;

SVANSSON, V ;

HAVE, P ;

ORVELL, C ;

APPEL, M ;

PEDERSEN, IR ;

DIETZ, HH ;

HENRIKSEN, P .

VETERINARY MICROBIOLOGY, 1993, 37 (1-2) :163-173

[5] DNA vaccine encoding nucleocapsid and surface proteins of wild type canine distemper virus protects its natural host against distemper [J].

Cherpillod, P ;

Tipold, A ;

Griot-Wenk, M ;

Cardozo, C ;

Schmid, I ;

Fatzer, R ;

Schobesberger, M ;

Zurbriggen, R ;

Bruckner, L ;

Roch, F ;

Vandevelde, M ;

Wittek, R ;

Zurbriggen, A .

VACCINE, 2000, 18 (26) :2927-2936

[6] Immunization with plasmid DNA encoding the hemagglutinin and the nucleoprotein confers robust protection against a lethal canine distemper virus challenge [J].

Dahl, L ;

Jensen, TH ;

Gottschalck, E ;

Karlskov-Mortensen, P ;

Jensen, TD ;

Nielsen, L ;

Andersen, MK ;

Buckland, R ;

Wild, TF ;

Blixenkrone-Moller, M .

VACCINE, 2004, 22 (27-28) :3642-3648

[7] Early DNA vaccination of puppies against canine distemper in the presence of maternally derived immunity [J].

Griot, C ;

Moser, C ;

Cherpillod, P ;

Bruckner, L ;

Wittek, R ;

Zurbriggen, A ;

Zurbriggen, R .

VACCINE, 2004, 22 (5-6) :650-654

[8]

Hammer Oyvind, 2001, Palaeontologia Electronica, V4, pUnpaginated

[9]

HANSEN M, 1972, ACTA PATH MICRO IM B, VB 80, P795

[10] Vaccination of neonates: Problem and issues [J].

Hodgins, Douglas C. ;

Shewen, Patricia E. .

VACCINE, 2012, 30 (09) :1541-1559

← 1 2 3 4 →