Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol

被引：27

作者：

Cao, Kaihui ^{[1
]}

Zhang, Kaiping ^{[2
]}

Ma, Muran ^{[1
]}

Ma, Junjie ^{[1
]}

Tian, Jianjun ^{[1
]}

Jin, Ye ^{[1
]}

机构：

[1] Inner Mongolia Agr Univ, Coll Food Sci & Technol, Hohhot 010000, Inner Mongolia, Peoples R China

[2] Inner Mongolia Business & Trade Vocat Coll, Dept Cooking & Food Proc, Hohhot, Peoples R China

来源：

FOOD SCIENCE & NUTRITION | 2021年 / 9卷 / 12期

基金：

中国国家自然科学基金;

关键词：

cholesterol; lactobacillus; mechanism; regulation; MESSENGER-RNA EXPRESSION; LIVER-X-RECEPTOR; PICK C1-LIKE 1; REDUCES CHOLESTEROL; METABOLISM; ACID; ABSORPTION; ASSIMILATION; MICE; TRANSCRIPTION;

D O I：

10.1002/fsn3.2600

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Hypercholesterolemia is the main cause of cardiovascular disease worldwide, and the regulation of cholesterol homeostasis is essential for human health. Lactobacillus is present in large quantities in the human intestine. As the normal flora in the gut, lactobacillus plays an important role in regulating metabolism in the human body. Lactobacillus can regulate the cholesterol content by regulating the expression of genes involved in cholesterol synthesis, metabolism, and absorption. This article reviews the biological effects and mechanisms of lactobacillus that mediate the expression of NPC1L1, CYP7A1, ABCG5, ABCG8, and other genes to inhibit cholesterol absorption, and discusses the mechanism of reducing cholesterol by lactobacillus in cells in vitro, to provide a theoretical basis for the development and utilization of lactobacillus resources.

引用

页码：6882 / 6891

页数：10

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