Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics

被引：357

作者：

Chamoli, Ambika ^{[1
]}

Gosavi, Abhishek S. ^{[1
]}

Shirwadkar, Urjita P. ^{[1
]}

Wangdale, Khushal V. ^{[1
]}

Behera, Santosh Kumar ^{[1
]}

Kurrey, Nawneet Kumar ^{[1
]}

Kalia, Kiran ^{[1
]}

Mandoli, Amit ^{[1
]}

机构：

[1] Govt India, Natl Inst Pharmaceut Educ & Res Ahmedabad NIPER A, Dept Biotechnol, Inst Natl Importance,Dept Pharmaceut,Minist Chem, Opp Air Force Stn, Gandhinagar 382355, Gujarat, India

来源：

ORAL ONCOLOGY | 2021年 / 121卷

关键词：

Oral cavity squamous cell carcinoma (OCSCC); Oral cavity cancer (OCC); Risk factor; Genetic alterations; Signaling; Diagnostic; Treatment; SIGNALING PATHWAY; NECK-CANCER; F-18-FDG PET/CT; FDG-PET/CT; HEAD; MANAGEMENT; TOBACCO; EXPRESSION; SURVIVAL; EGFR;

D O I：

10.1016/j.oraloncology.2021.105451

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oral cavity squamous cell carcinoma (OCSCC) is the most common malignancy of the oral cavity. The substantial risk factors for OCSCC are the consumption of tobacco products, alcohol, betel quid, areca nut, and genetic alteration. However, technological advancements have occurred in treatment, but the survival decreases with late diagnosis; therefore, new methods are continuously being investigated for treatment. In addition, the rate of secondary tumor formation is 3-7% yearly, which is incomparable to other malignancies and can lead to the disease reoccurrence. Oral cavity cancer (OCC) arises from genetic alterations, and a complete understanding of the molecular mechanism involved in OCC is essential to develop targeted treatments. This review aims to update the researcher on oral cavity cancer, risk factors, genetic alterations, molecular mechanism, classification, diagnostic approaches, and treatment.

引用

页数：9

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