Newly synthesized triazole-based Schiff base ligands and their Co(II) complexes as antimicrobial and anticancer agents: Chemical synthesis, structure and biological investigations

被引：21

作者：

Deodware, Sachin A. ^{[1
]}

Barache, Umesh B. ^{[1
]}

Chanshetti, Umakant B. ^{[2
]}

Sathe, D. J. ^{[3
]}

Ashok, Ubale Panchsheela ^{[4
,5
]}

Gaikwad, Shashikant H. ^{[1
]}

Kollur, Shiva Prasad ^{[6
]}

机构：

[1] Shri Shivaji Mahavidyalaya, Chem Res Lab, Dept Chem, Solapur 413411, Maharashtra, India

[2] Jawahar Arts Sci & Commerce Coll, Osmanabad 413501, Maharashtra, India

[3] Kolhapur Inst Technol Coll Engn Autonomous, Dept Chem, Kolhapur 416234, Maharashtra, India

[4] Rajaram Coll, Dept Chem, Kolhapur 416004, Maharashtra, India

[5] NK Orchid Coll Engn & Technol, Solapur 413002, Maharashtra, India

[6] Amrita Vishwa Vidyapeetham, Dept Sci, Amrita Sch Arts & Sci, Mysuru Campus, Mysuru 570026, Karnataka, India

来源：

RESULTS IN CHEMISTRY | 2021年 / 3卷

关键词：

1,2,4-triazole; Schiff base; Co(II) complexes; Antimicrobial; Anticancer; CU(II) COMPLEXES; NI(II); 1,2,4-TRIAZOLE; CYTOTOXICITY; NICKEL(II); COBALT(II); IRON(III); ZN(II);

D O I：

10.1016/j.rechem.2021.100162

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The new Schiff base ligands 4-(2'/3'/4'-nitrobenzelideneimino)-3-methyl/ethyl-5-mercapto-1,2,4-triazole and their Co(II) metal complexes were synthesized and characterized by elemental analysis, magnetic moment measurements, thermal studies, electronic absorption and NMR spectroscopy. The ligands were synthesized by condensation of 4-amino-5-mercapto-3-methyl/ethyl-1,2,4-triazole with 2/3/4-nitrobenzaldehyde. On the basis of electronic absorption spectral data and magnetic susceptibility measurements, the octahedral geometry has been proposed for all the Co(II) complexes. Further, the ligands and Co(II) complexes have been screened for their antimicrobial activities against bacteria (Staphylococcus aureus, Pseudomonas aeruginosa) and fungi (Aspergillus niger and Candida albicans). Furthermore, the synthesized compounds were also screened for anticancer activity on human cancer cell lines such as breast (MCF7), lung (NCI-H226), prostate (PC-3) and ovary (OVCAR-3) by sulforhodamine-B (SRB) colorimetric assay.

引用

页数：9

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