Vertical transmission of the hepatitis C virus to infants of anti-human immunodeficiency virus-negative mothers: Molecular evolution of hypervariable region 1 in prenatal and perinatal or postnatal infections

被引：9

作者：

Caudai, C

Battiata, M

Riccardi, MP

Toti, M

Bonazza, P

Padula, MG

Pianese, M

Valensin, PE

机构：

[1] Univ Siena, Dept Mol Biol, Microbiol Sect, I-53100 Siena, Italy

[2] Misericordia Hosp, Div Infect Dis, Grosseto, Italy

[3] Misericordia Hosp, Div Pediat, Grosseto, Italy

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2003年 / 41卷 / 08期

关键词：

D O I：

10.1128/JCM.41.8.3955-3959.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a prospective study of 33 infants born to hepatitis C virus (HCV)-positive human immunodeficiency virus-negative mothers the vertical transmission of HCV occurred in 6.8%. The evolution of HCV infection in two babies was studied from birth up to 5 or 6 years of age, and the sequencing of the hypervariable region (HVR) of the putative envelope-encoding E2 region of the HCV genome was performed. The HVR1 sequence variability and the different serological profiles during follow-up could reflect the differences in HCV transmission routes, HCV genotypes, and clinical evolution of infection.

引用

页码：3955 / 3959

页数：5

共 21 条

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