Peroxide mediates ethanol-induced cytotoxicity in PC12 cells

被引：20

作者：

Li, YX ^{[1
]}

Walker, DW ^{[1
]}

King, MA ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Dept Neurosci, Gainesville, FL 32610 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2001年 / 30卷 / 04期

关键词：

ethanol; hydrogen peroxide; PC12; cell; oxidative stress; free radicals;

D O I：

10.1016/S0891-5849(00)00484-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pheochromocytoma (PC12) cell cultures exhibited a loss of cells and increase in intracellular oxidative stress when exposed to ethanol (EtOH) for 24 h. Catalase, an enzyme that hydrolyzes hydrogen peroxide (H2O2) to O-2 and H2O can attenuate EtOH-induced cell loss and oxidative stress in PC12 cells. This study provides the first clear evidence that oxidative stress in the form of elevated intracellular H2O2 is a primary mechanism of EtOH neurotoxicity in PC12 cells. (C) 2001 Elsevier Science Inc.

引用

页码：389 / 392

页数：4

共 50 条

[41] Free radicals and ethanol-induced cytotoxicity in neural crest cells [J].

Chen, SY ;

Sulik, KK .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1996, 20 (06) :1071-1076

[42] Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells [J].

Mendonca, Leonardo Meneghin ;

dos Santos, Graciela Cristina ;

Antonucci, Gilmara Ausech ;

dos Santos, Antonio Cardozo ;

Pires Bianchi, Maria de Lourdes ;

Greggi Antunes, Lusania Maria .

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2009, 675 (1-2) :29-34

[43] Structure-activity relationships of quercetin in antagonizing hydrogen peroxide-induced calcium dysregulation in PC12 cells [J].

Wang, H ;

Joseph, JA .

FREE RADICAL BIOLOGY AND MEDICINE, 1999, 27 (5-6) :683-694

[44] The protective effect of trihexyphenidyl on the beta-amyloid peptide 25-35-induced cytotoxicity in PC12 cells [J].

Liu, Zhen-Zhen ;

Ji, Bian-Sheng .

CLINICAL AND EXPERIMENTAL MEDICINE, 2010, 10 (04) :237-243

[45] A water extract of Curcuma longa L. (Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells [J].

Koo, BS ;

Lee, WC ;

Chung, KH ;

Ko, JH ;

Kim, CH .

LIFE SCIENCES, 2004, 75 (19) :2363-2375

[46] Mechanism of apoptosis induced by copper in PC12 cells [J].

Kawakami, Masaki ;

Inagawa, Rieko ;

Hosokawa, Toshiyuki ;

Saito, Takeshi ;

Kurasaki, Masaaki .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (06) :2157-2164

[47] Aspartame-induced apoptosis in PC12 cells [J].

Horio, Yukari ;

Sun, Yongkun ;

Liu, Chuang ;

Saito, Takeshi ;

Kurasaki, Masaaki .

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2014, 37 (01) :158-165

[48] Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells [J].

Yang, Yoo Jung ;

Lee, Jae Joon ;

Jin, Chun Mei ;

Lim, Sung Cil ;

Lee, Myung Koo .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 587 (1-3) :57-64

[49] Protective effects of Paeonia lactiflora pall on hydrogen peroxide-induced apoptosis in PC12 cells [J].

Lee, Sang-Myeon ;

Yoon, Mi-Young ;

Park, Hae-Ryong .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2008, 72 (05) :1272-1277

[50] Effects of tributyltin chloride on L-DOPA-induced cytotoxicity in PC12 cells [J].

Lee, Jae Joon ;

Kim, Yu Mi ;

Park, Seung-Kook ;

Lee, Myung Koo .

ARCHIVES OF PHARMACAL RESEARCH, 2006, 29 (08) :645-650

← 1 2 3 4 5 →