Peroxide mediates ethanol-induced cytotoxicity in PC12 cells

被引：20

作者：

Li, YX ^{[1
]}

Walker, DW ^{[1
]}

King, MA ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Dept Neurosci, Gainesville, FL 32610 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2001年 / 30卷 / 04期

关键词：

ethanol; hydrogen peroxide; PC12; cell; oxidative stress; free radicals;

D O I：

10.1016/S0891-5849(00)00484-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pheochromocytoma (PC12) cell cultures exhibited a loss of cells and increase in intracellular oxidative stress when exposed to ethanol (EtOH) for 24 h. Catalase, an enzyme that hydrolyzes hydrogen peroxide (H2O2) to O-2 and H2O can attenuate EtOH-induced cell loss and oxidative stress in PC12 cells. This study provides the first clear evidence that oxidative stress in the form of elevated intracellular H2O2 is a primary mechanism of EtOH neurotoxicity in PC12 cells. (C) 2001 Elsevier Science Inc.

引用

页码：389 / 392

页数：4

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