Potentiation of Natural Killer Cells for Cancer Immunotherapy: A Review of Literature

被引：51

作者：

Lowry, Lacy E. ^{[1
,3
]}

Zehring, William A. ^{[2
]}

机构：

[1] Geisinger Commonwealth Sch Med, Dept Basic Sci, Scranton, PA USA

[2] Geisinger Commonwealth Sch Med, Dept Biochem, Scranton, PA 18509 USA

[3] San Antonio Mil Med Ctr, San Antonio, TX USA

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

关键词：

cancer; immunology; immunotherapy; natural killer cells; cellular heterogeneity; ACUTE MYELOID-LEUKEMIA; STEM-CELLS; NK CELLS; IMMUNE-SYSTEM; TRANSPLANTATION; RECEPTOR; DIFFERENTIATION; DYSFUNCTION; INHIBITION; MEMORY;

D O I：

10.3389/fimmu.2017.01061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is widely acknowledged that the human immune system plays a crucial role in preventing the formation and progression of innumerable types of cancer (1). The mechanisms by which this occurs are numerous, including contributions from both the innate and adaptive immune systems. As such, immunotherapy has long been believed to be an auspicious solution in the treatment of malignancy (2). Recent research has highlighted the promise of natural killer (NK) cells as a more directed immunotherapy approach. This paper will focus on the methods of potentiation of NK cells for their use in cancer therapy.

引用

页数：7

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