Fluoroquinolone Prophylaxis Against Febrile Neutropenia in Areas With High Fluoroquinolone Resistance-An Asian Perspective

被引：11

作者：

Ng, Esther Shu-Ting ^{[1
]}

Liew, Yixin ^{[3
]}

Koh, Liang Piu ^{[2
]}

Hsu, Li Yang ^{[1
]}

机构：

[1] Natl Univ Hlth Syst, Dept Med, Singapore, Singapore

[2] Natl Univ Hlth Syst, Dept Hematol Oncol, Singapore, Singapore

[3] Singapore Gen Hosp, Dept Pharm, Singapore 0316, Singapore

来源：

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION | 2010年 / 109卷 / 09期

关键词：

antimicrobial resistance; Asia; febrile neutropenia; fluoroquinolone; prophylaxis; COLONY-STIMULATING FACTOR; BLOOD-STREAM INFECTIONS; CANCER-PATIENTS; ESCHERICHIA-COLI; CIPROFLOXACIN PROPHYLAXIS; ANTIMICROBIAL PROPHYLAXIS; ANTIBIOTIC-PROPHYLAXIS; PSEUDOMONAS-AERUGINOSA; SOLID TUMORS; CHEMOTHERAPY;

D O I：

10.1016/S0929-6646(10)60102-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Febrile neutropenia remains a major cause of morbidity and mortality in patients receiving chemotherapy. Major prophylactic strategies include granulocyte colony-stimulating factor and antibiotics, the most widely used of which are fluoroquinolones. While fluoroquinolone prophylaxis has been shown to be effective in areas where fluoroquinolone resistance is low, this same efficacy has not been proven in areas where resistance is high, such as in Asia. Given the increase in antimicrobial resistance with the use of prophylaxis, the risks and benefits of this strategy need to be carefully considered. This review presents the evidence for and against fluoroquinolone prophylaxis in areas of high fluoroquinolone resistance.

引用

页码：624 / 631

页数：8

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