Filamentous growth is a general feature of Candida auris clinical isolates

被引：41

作者：

Fan, Shuru ^{[1
]}

Yue, Huizhen ^{[2
]}

Zheng, Qiushi ^{[1
]}

Bing, Jian ^{[1
]}

Tian, Sufei ^{[3
]}

Chen, Jingjing ^{[3
]}

Ennis, Craig L. ^{[4
,5
]}

Nobile, Clarissa J. ^{[5
]}

Huang, Guanghua ^{[1
]}

Du, Han ^{[1
]}

机构：

[1] Fudan Univ, Huashan Hosp, Sch Life Sci,State Key Lab Genet Engn, Inst Biomed Sci,Dept Infect Dis, Shanghai, Peoples R China

[2] Chinese Acad Sci, State Key Lab Mycol, Inst Microbiol, Beijing, Peoples R China

[3] China Med Univ, Dept Lab Med, Affiliated Hosp 1, Shenyang, Peoples R China

[4] Univ Calif Merced, Dept Mol & Cell Biol, Merced, CA USA

[5] Univ Calif Merced, Quantitat & Syst Biol Grad Program, Merced, CA USA

来源：

MEDICAL MYCOLOGY | 2021年 / 59卷 / 07期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Candida auris; filamentation; morphological plasticity; virulence; antifungal resistance;

D O I：

10.1093/mmy/myaa116

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A striking feature of pathogenic Candida species is morphological plasticity that facilitates environmental adaptation and host infection. Candida auris is an emerging multidrug-resistant fungal pathogen first described in Japan in 2009. In this study, we demonstrate that clinical isolates of C. auris have multiple colony and cellular morphologies including the yeast, filamentous, aggregated, and elongated forms. This phenotypic diversity has been observed in eight clinical isolates of C. auris representing four major genetic clades, suggesting that it could be a general characteristic. We further demonstrate that different cell types of C. auris exhibit distinct antifungal resistance and virulence properties in a Galleria mellonella infection model. Our findings imply that morphological diversity is an important biological feature of C. auris and could be a contributor to its emergence and rapid prevalence worldwide. Lay Summary Candida auris is an emerging multidrug-resistant fungal pathogen. Morphological analyses indicate that filamentation is a general feature of clinical isolates of C. auris. This ability is associated with antifungal resistance and virulence.

引用

页码：734 / 740

页数：7

共 16 条

[1] Pseudohyphal Growth of the Emerging Pathogen Candida auris Is Triggered by Genotoxic Stress through the S Phase Checkpoint [J].