Calcium channels and Ca2+ fluctuations in sperm physiology

被引:143
作者
Darszon, A [1 ]
Nishigaki, T [1 ]
Wood, C [1 ]
Treviño, CL [1 ]
Felix, R [1 ]
Beltrán, C [1 ]
机构
[1] Natl Polytech Inst, Ctr Res & Adv Studies, Dept Physiol, Mexico City 07300, DF, Mexico
来源
INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 243 | 2005年 / 243卷
基金
英国惠康基金;
关键词
sperm Ca2+ channels; acrosome reaction; spermatogenesis; sperm motility; chemotaxis; sperm capacitation; ion channels; single-cell imaging;
D O I
10.1016/S0074-7696(05)43002-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Generating new life in animals by sexual reproduction depends on adequate communication between mature and competent male and female gametes. Ion channels are instrumental in the dialogue between sperm, its environment, and the egg. The ability of sperm to swim to the egg and fertilize it is modulated by ion permeability changes induced by environmental cues and components of the egg outer layer. Ca2+ is probably the key messenger in this information exchange. It is therefore not surprising that different Ca2+-permeable channels are distinctly localized in these tiny specialized cells. New approaches to measure sperm currents, intracellular Ca2+ membrane potential, and intracellular pH with fluorescent probes, patch-clamp recordings, sequence information, and heterologous expression are revealing how sperm channels participate in fertilization. Certain sperm ion channels are turning out to be unique, making them attractive targets for contraception and for the discovery of novel signaling complexes.
引用
收藏
页码:79 / 172
页数:94
相关论文
共 603 条
[1]   Ca2+-calmodulin inhibits Ca2+ release mediated by type-1,-2 and-3 inositol trisphosphate receptors [J].
Adkins, CE ;
Morris, SA ;
De Smedt, H ;
Sienaert, I ;
Török, K ;
Taylor, CW .
BIOCHEMICAL JOURNAL, 2000, 345 :357-363
[2]   The extragenomic action of progesterone on human spermatozoa: Evidence for a ubiquitous response that is rapidly down-regulated [J].
Aitken, RJ ;
Buckingham, DW ;
Irvine, DS .
ENDOCRINOLOGY, 1996, 137 (09) :3999-4009
[3]   Sulfated polysaccharides from the egg jelly layer are species-specific inducers of acrosomal reaction in sperms of sea urchins [J].
Alves, AP ;
Mulloy, B ;
Diniz, JA ;
Mourao, PAS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (11) :6965-6971
[4]   Females of the sea urchin Strongylocentrotus purpuratus differ in the structures of their egg jelly sulfated fucans [J].
Alves, AP ;
Mulloy, B ;
Moy, GW ;
Vacquier, VD ;
Mourao, PAS .
GLYCOBIOLOGY, 1998, 8 (09) :939-946
[5]   Cloning of a novel one-repeat calcium channel-like gene [J].
Arias, JM ;
Murbartián, J ;
Perez-Reyes, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 303 (01) :31-36
[6]   Auxiliary subunits: essential components of the voltage-gated calcium channel complex [J].
Arikkath, J ;
Campbell, KP .
CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (03) :298-307
[7]   Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease [J].
Arnaout, MA .
ANNUAL REVIEW OF MEDICINE, 2001, 52 :93-123
[8]   Control of the low voltage-activated calcium channel of mouse sperm by egg ZP3 and by membrane hyperpolarization during capacitation [J].
Arnoult, C ;
Kazam, IG ;
Visconti, PE ;
Kopf, GS ;
Villaz, M ;
Florman, HM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6757-6762
[9]   Activation of mouse sperm T-type Ca2+ channels by adhesion to the egg zona pellucida [J].
Arnoult, C ;
Cardullo, RA ;
Lemos, JR ;
Florman, HM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :13004-13009
[10]   ZP3-dependent activation of sperm cation channels regulates acrosomal secretion during mammalian fertilization [J].
Arnoult, C ;
Zeng, Y ;
Florman, HM .
JOURNAL OF CELL BIOLOGY, 1996, 134 (03) :637-645