Therapeutic management of HIV-infected patients with chronic kidney disease

被引：11

作者：

Alfano, Gaetano ^{[1
,2
]}

Guaraldi, Giovanni ^{[3
]}

Fontana, Francesco ^{[2
]}

Bellasi, Antonio ^{[4
]}

Cappelli, Gianni ^{[1
,2
]}

机构：

[1] Univ Hosp Modena & Reggio Emilia, Nephrol Sect, Surg Med & Dent Dept Morphol Sci, Via Pozzo 71, I-41124 Modena, Italy

[2] Univ Hosp Modena, Nephrol Dialysis & Transplant Unit, Modena, Italy

[3] Univ Hosp Modena, Clin Infect Dis, Modena, Italy

[4] ASST Papa Giovanni XXIII, Osped Bergamo, Dept Res, Innovat,Brand Reputat, Bergamo, Italy

来源：

JOURNAL OF NEPHROLOGY | 2020年 / 33卷 / 04期

关键词：

HIV; Chronic kidney disease; Antiretroviral therapy; Dialysis; Kidney transplantation; Kidney waiting list; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C VIRUS; COMBINATION ANTIRETROVIRAL THERAPY; AMBULATORY PERITONEAL-DIALYSIS; TENOFOVIR DISOPROXIL FUMARATE; CLINICAL-PRACTICE GUIDELINE; STAGE RENAL-DISEASE; TRANSPLANT RECIPIENTS; RISK-FACTORS; OPEN-LABEL;

D O I：

10.1007/s40620-020-00701-8

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

CKD and HIV infection are two chronic diseases impacting heavily on the survival of the affected patients. The interplay between HIV infection and chronic kidney disease (CKD) is complex and interactions occur at multiple levels. Approach to the management of HIV-infected patients requires special attention to face the numerous therapeutic difficulties ranging from drug-drug interactions to drug-toxicity. The most effective strategy is targeted to suppression of HIV viral load, as it dramatically changes the prognosis of the patients as well as prevents the development of HIV-associated kidney disease. As shown in this review, the approach to the therapeutic management of CKD in the setting of HIV infection varies in relation to the degree of renal impairment.

引用

页码：699 / 713

页数：15

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