Posttraumatic Stress Disorder: An Immunological Disorder?

被引：47

作者：

Wang, Zhewu ^{[1
,2
]}

Caughron, Blaine ^{[3
]}

Young, M. Rita I. ^{[3
,4
]}

机构：

[1] Ralph H Johnson VA Med Ctr, Mental Hlth Serv, Charleston, SC USA

[2] Med Univ South Carolina, Dept Psychiat, Charleston, SC USA

[3] Ralph H Johnson VA Med Ctr, Res Serv, Charleston, SC 29401 USA

[4] Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA

来源：

FRONTIERS IN PSYCHIATRY | 2017年 / 8卷

关键词：

Immune; Inflammation; PTSD; Stress; Disorder; COMBAT-RELATED PTSD; CORONARY-HEART-DISEASE; T-LYMPHOCYTE FUNCTION; QUALITY-OF-LIFE; MICROGLIAL ACTIVATION; EXOGENOUS SEROTONIN; CYTOKINE LEVELS; CELL CARCINOMA; MOUSE MODEL; TNF-ALPHA;

D O I：

10.3389/fpsyt.2017.00222

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Patients with posttraumatic stress disorder (PTSD) exhibit an increased state of inflammation. Various animal models for PTSD have shown some of the same immune imbalances as have been shown in human subjects with PTSD, and some of these studies are discussed in this review. However, animal studies can only indirectly implicate immune involvement in PTSD in humans. This review of mainly studies with human subjects focuses on dissecting the immunological role in the pathogenesis of PTSD following initial trauma exposure. It addresses both the inflammatory state associated with PTSD and the immune imbalance between stimulatory and inhibitory immune mediators, as well as variables that can lead to discrepancies between analyses. The concept of immunological treatment approaches is proposed for PTSD, as new treatments are needed for this devastating disorder that is affecting unprecedented numbers of Veterans from the long-standing wars in the Middle East and which affects civilians following severe trauma.

引用

页数：7

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