Meta-analysis of multi-jurisdictional health administrative data from distributed networks approximated individual-level multivariable regression

被引：7
作者：
Dheri, Aman K. [1 ,2 ]
Kuenzig, M. Ellen [3 ,4 ]
Mack, David R. [1 ,5 ,6 ]
Murthy, Sanjay K. [2 ,7 ,8 ]
Kaplan, Gilaad G. [9 ,10 ]
Donelle, Jessy [7 ]
Smith, Glenys [7 ]
Benchimol, Eric, I [1 ,2 ,3 ,4 ,5 ,6 ,7 ,11 ]
机构：
[1] CHEO, Div Gastroenterol Hepatol & Nutr, Childrens Hosp Eastern Ontario CHEO, Inflammatory Bowel Dis Ctr, Ottawa, ON, Canada
[2] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada
[3] Hosp Sick Children, SickKids Inflammatory Bowel Dis Ctr, Div Gastroenterol Hepatol & Nutr, Toronto, ON, Canada
[4] Hosp Sick Children, SickKids Res Inst, Child Hlth Evaluat Sci, Toronto, ON, Canada
[5] CHEO Res Inst, Ottawa, ON, Canada
[6] Univ Ottawa, Dept Pediat, Ottawa, ON, Canada
[7] ICES, Toronto, ON, Canada
[8] Univ Ottawa, Dept Med, Ottawa, ON, Canada
[9] Univ Calgary, Dept Med, Calgary, AB, Canada
[10] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada
[11] Univ Toronto, Hosp Sick Children, Dept Paediat, Toronto, ON, Canada
来源：
JOURNAL OF CLINICAL EPIDEMIOLOGY | 2022年 / 149卷
基金：
加拿大健康研究院;
关键词：
Routinely collected health data; Inflammatory bowel disease; Pediatrics; Health services research; Health administrative data; Methodology; Multivariable regression analysis; AGGREGATE; INFORMATION; OUTCOMES; DISEASE;
D O I：
10.1016/j.jclinepi.2022.05.006
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
<bold>Background </bold>and Objectives: Compare meta-analysis in a distributed network to individual-level analysis for assessment of time trends of health services utilization with health administrative data.<bold>Methods</bold>: We used administrative data from Ontario, Canada to analyze temporal trends in pediatric inflammatory bowel disease health services use. Beta coefficients were obtained using negative binomial, logistic, and Cox proportional hazards regression models. We replicated the individual-level analyses in each Ontario Local Health Integration Network (LHIN), then metaanalyzed aggregate trends using both fixed and random effects meta-analysis. We compared the pooled estimates of effect with individual-level analysis.<bold>Results</bold>: Beta coefficients, summary effect estimates, and 95% confidence intervals (CIs) from the meta-analysis of data from distributed networks were not different than those from individual-level data, regardless of meta-analytic approach used. For example, the 5-year odds ratio of colectomy in ulcerative colitis using individual-level analysis was 0.978 (95% CI 0.950 to 1.007) compared to distributed network fixed effects meta-analysis: 0.982 (95% CI 0.950 to 1.015), and random effects meta-analysis: 0.982 (95% CI 0.950
引用
收藏
页码：23 / 35
页数：13
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