Pulmonary Complications in Hematopoietic Stem Cell Transplant Recipients-A Clinician Primer

被引：27

作者：

Astashchanka, Anna ^{[1
]}

Ryan, Joseph ^{[2
]}

Lin, Erica ^{[1
]}

Nokes, Brandon ^{[1
]}

Jamieson, Catriona ^{[3
]}

Kligerman, Seth ^{[4
]}

Malhotra, Atul ^{[1
]}

Mandel, Jess ^{[1
]}

Joshua, Jisha ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Pulm Crit Care Sleep Med & Physiol, La Jolla, CA 92121 USA

[2] Scripps Clin, Div Hematol & Oncol, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Div Regenerat Med, Dept Med, Sanford Stem Cell Clin Ctr,Moores Canc Ctr, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Div Cardiothorac Radiol, La Jolla, CA 92121 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 15期

关键词：

post-HSCT; PERDS; DAH; IPS; bronchiolitis obliterans syndrome; RESPIRATORY SYNCYTIAL VIRUS; IDIOPATHIC PNEUMONIA SYNDROME; VERSUS-HOST-DISEASE; BRONCHIOLITIS OBLITERANS SYNDROME; DIFFUSE ALVEOLAR HEMORRHAGE; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; BONE-MARROW-TRANSPLANTATION; CYTOMEGALOVIRUS PNEUMONIA; RISK-FACTORS; HEMATOLOGIC MALIGNANCIES;

D O I：

10.3390/jcm10153227

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematopoietic stem cell transplants (HSCT) are becoming more widespread as a result of optimization of conditioning regimens and prevention of short-term complications with prophylactic antibiotics and antifungals. However, pulmonary complications post-HSCT remain a leading cause of morbidity and mortality and are a challenge to clinicians in both diagnosis and treatment. This comprehensive review provides a primer for non-pulmonary healthcare providers, synthesizing the current evidence behind common infectious and non-infectious post-transplant pulmonary complications based on time (peri-engraftment, early post-transplantation, and late post-transplantation). Utilizing the combination of timing of presentation, clinical symptoms, histopathology, and radiographic findings should increase rates of early diagnosis, treatment, and prognostication of these severe illness states.

引用

页数：20

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