PARP INHIBITION: ADVANCING THROUGH THE ONCOLYTIC ARENA

被引：3

作者：

Gien, L. T. ^{[2
]}

Mackay, H. J. ^{[1
]}

机构：

[1] Univ Toronto, Princess Margaret Hosp, Toronto, ON M5G 2M9, Canada

[2] Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, Toronto, ON M4N 3M5, Canada

来源：

DRUGS OF THE FUTURE | 2010年 / 35卷 / 06期

关键词：

POLY(ADP-RIBOSE) POLYMERASE INHIBITOR; DOUBLE-STRAND BREAKS; DNA-REPAIR DEFECT; BRCA MUTANT-CELLS; SPORADIC BREAST; MAMMARY-TUMORS; PHASE-I; TEMOZOLOMIDE; ABT-888; CANCER;

D O I：

10.1358/dof.2010.035.06.1493933

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Poly(ADP-ribose)polymerase 1 (PARP-1) is an essential enzyme in the repair of single-strand breaks in DNA via the base excision repair pathway and has become an important novel target in cancer therapy. PARP inhibitors represent a major breakthrough for patients with hereditary BRCA-associated cancers as a promising new class of anticancer agents. This review will summarize PARP inhibition, including the mechanism of action, its role in the treatment of BRCA1- and 2-associated cancers, the promise of combination therapy with cytotoxic agents and future directions for PARP inhibition in the clinical setting.

引用

页码：481 / 487

页数：7

共 73 条

[21] AZD2281 (KU-0059436), a PARP (poly ADP-ribose polymerase) inhibitor with single agent anticancer activity in patients with BRCA deficient ovarian cancer: Results from a phase I study
Fong, P. C.
Boss, D. S.
Carden, C. P.
Roelvink, M.
De Greve, J.
Gourley, C. M.
Carmichael, J.
De Bono, J. S.
Schellens, J. H.
Kaye, S. B.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
[22] Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers.
Fong, Peter C.
Boss, David S.
Yap, Timothy A.
Tutt, Andrew
Wu, Peijun
Mergui-Roelvink, Marja
Mortimer, Peter
Swaisland, Helen
Lau, Alan
O'Connor, Mark J.
Ashworth, Alan
Carmichael, James
Kaye, Stan B.
Schellens, Jan H. M.
de Bono, Johann S.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (02) : 123 - 134
[23] RISKS OF CANCER IN BRCA1-MUTATION CARRIERS
FORD, D
EASTON, DF
BISHOP, DT
NAROD, SA
GOLDGAR, DE
HAITES, N
MILNER, B
ALLAN, L
PONDER, BAJ
PETO, J
SMITH, S
STRATTON, M
LENOIR, GM
FEUNTEUN, J
LYNCH, H
ARASON, A
BARKARDOTTIR, R
EGILSSON, V
BLACK, DM
KELSELL, D
SPURR, N
DEVILEE, P
CORNELISSE, CJ
VARSEN, H
BIRCH, JM
SKOLNICK, M
SANTIBANEZKOREF, MS
TEARE, D
STEEL, M
PORTER, D
COHEN, BB
CAROTHERS, A
SMYTH, E
WEBER, B
NEWBOLD, B
BOEHNKE, M
COLLINS, FS
CANNONALBRIGHT, LA
GOLDGAR, D
[J]. LANCET, 1994, 343 (8899) : 692 - 695
[24] The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability
Gudmundsdottir, K.
Ashworth, A.
[J]. ONCOGENE, 2006, 25 (43) : 5864 - 5874
[25] Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy
Hay, T
Jenkins, H
Sansom, OJ
Martin, NMB
Smith, GCM
Clarke, AR
[J]. CANCER RESEARCH, 2005, 65 (22) : 10145 - 10148
[26] Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous Brca2/p53-Mutant Mammary Tumors In vivo and Delays Tumor Relapse in Combination with Carboplatin
Hay, Trevor
Matthews, James R.
Pietzka, Lucie
Lau, Alan
Cranston, Aaron
Nygren, Anders O. H.
Douglas-Jones, Anthony
Smith, Graeme C. M.
Martin, Niall M. B.
O'Connor, Mark
Clarke, Alan R.
[J]. CANCER RESEARCH, 2009, 69 (09) : 3850 - 3855
[27] Genome maintenance mechanisms for preventing cancer
Hoeijmakers, JHJ
[J]. NATURE, 2001, 411 (6835) : 366 - 374
[28] Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity
Horton, Terzah M.
Jenkins, Gaye
Pati, Debananda
Zhang, Linna
Dolan, M. Eileen
Ribes-Zamora, Albert
Bertuch, Alison A.
Blaney, Susan M.
Delaney, Shannon L.
Hegde, Madhuri
Berg, Stacey L.
[J]. MOLECULAR CANCER THERAPEUTICS, 2009, 8 (08) : 2232 - 2242
[29] EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
Hughes-Davies, L
Huntsman, D
Ruas, M
Fuks, F
Bye, J
Chin, SF
Milner, J
Brown, LA
Hsu, F
Gilks, B
Nielsen, T
Schulzer, M
Chia, S
Ragaz, J
Cahn, A
Linger, L
Ozdag, H
Cattaneo, E
Jordanova, ES
Schuuring, E
Yu, DS
Venkitaraman, A
Ponder, B
Doherty, A
Aparicio, S
Bentley, D
Theillet, C
Ponting, CP
Caldas, C
Kouzarides, T
[J]. CELL, 2003, 115 (05) : 523 - 535
[30] Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and-2 Mutant Tumors
Jones, Philip
Altamura, Sergio
Boueres, Julia
Ferrigno, Federica
Fonsi, Massimiliano
Giomini, Claudia
Lamartina, Stefania
Monteagudo, Edith
Ontoria, Jesus M.
Orsale, Maria Vittoria
Palumbi, Maria Cecilia
Pesci, Silvia
Roscilli, Giuseppe
Scarpelli, Rita
Schultz-Fademrecht, Carsten
Toniatti, Carlo
Rowley, Michael
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (22) : 7170 - 7185

← 1 2 3 4 5 6 7 8 →