Dysfunction of the Glymphatic System as a Potential Mechanism of Perioperative Neurocognitive Disorders

被引：22
作者：
Ren, Xuli [1 ]
Liu, Shan [2 ]
Lian, Chuang [3 ]
Li, Haixia [2 ]
Li, Kai [1 ]
Li, Longyun [1 ]
Zhao, Guoqing [1 ,4 ]
机构：
[1] Jilin Univ, Dept Anaesthesiol, China Japan Union Hosp, Changchun, Peoples R China
[2] Jilin Univ, Dept Neurol, Affiliated Hosp 1, Changchun, Peoples R China
[3] Jilin City Peoples Hosp, Dept Anaesthesiol, Jilin, Jilin, Peoples R China
[4] Jilin Univ, Changchun, Peoples R China
来源：
FRONTIERS IN AGING NEUROSCIENCE | 2021年 / 13卷
关键词：
glymphatic system; postoperative complications; postoperative neuropathy; postoperative cognitive dysfunction; perioperative neurocognitive disorders; BLOOD-BRAIN-BARRIER; POSTOPERATIVE COGNITIVE DYSFUNCTION; CEREBROSPINAL-FLUID; GENERAL-ANESTHESIA; ELDERLY-PATIENTS; REM-SLEEP; NEUROINFLAMMATION; SURGERY; DISEASE; FLOW;
D O I：
10.3389/fnagi.2021.659457
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Perioperative neurocognitive disorder (PND) frequently occurs in the elderly as a severe postoperative complication and is characterized by a decline in cognitive function that impairs memory, attention, and other cognitive domains. Currently, the exact pathogenic mechanism of PND is multifaceted and remains unclear. The glymphatic system is a newly discovered glial-dependent perivascular network that subserves a pseudo-lymphatic function in the brain. Recent studies have highlighted the significant role of the glymphatic system in the removal of harmful metabolites in the brain. Dysfunction of the glymphatic system can reduce metabolic waste removal, leading to neuroinflammation and neurological disorders. We speculate that there is a causal relationship between the glymphatic system and symptomatic progression in PND. This paper reviews the current literature on the glymphatic system and some perioperative factors to discuss the role of the glymphatic system in PND.
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页数：14
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