Association of the F13A1 Val34Leu polymorphism and recurrent pregnancy loss: A meta-analysis

Objective: Factor XIII (FXIII) plays role in stabilizing the linkage between fibrins during blood clotting and has been implicated in recurrent pregnancy loss (RPL). The relationship between the Val34Leu polymorphism in F13A1, which encodes the enzymatic subunit of FXIII, and RPL is unclear. The aim of this meta-analysis was to evaluate the association betweenF13A1 Val34Leu and the risk of RPL. Study design: We performed a meta-analysis of 11 studies involving 1092 cases and 678 controls using published liteiature from PubMed and Embase. Results: We detected an association in recessive (Val/Val vs. Val/Leu + Leu/Leu; OR=0.71, 95% CI = 0.51-0.99, P=0.04), and one of the two co-dominant (Val/Val vs. Val/Leu; OR = 0.71, 95% CI = 0.52-0.98, P=0.03) models of in heritance. Subgroup analysis revealed that the F13A1 Val34Leu polymorphism was associated with RPL in Asians (Val vs. Leu; OR=0.53, 0 = 0.33-0.85, P=0.01). However, there was no association between F13A1 Val34Leu and RPL in Europeans and South Americans. Conclusion: Our meta-analysis supports an association between F13A1 Val34Leu and RPL. (C) 2017 Elsevier B.V. All rights reserved.