Regioselective conversion of alkynes to 4-substituted and 3,4-disubstituted isoxazoles using titanium-catalyzed multicomponent coupling reactions

被引：26

作者：

Dissanayake, Amila A. ^{[1
]}

Odom, Aaron L. ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

来源：

TETRAHEDRON | 2012年 / 68卷 / 03期

基金：

美国国家科学基金会;

关键词：

Heterocycles; Isoxazoles; Multicomponent coupling; Titanium; Alkyne; ETA(1)-PYRROLYL COMPLEXES; DERIVATIVES; HYDROAMINATION; REDUCTION; N; N-DI(PYRROLYL-ALPHA-METHYL)-N-METHYLAMINE; HETEROCYCLES; CHEMISTRY; AZADIENES; OXIDES; AGENTS;

D O I：

10.1016/j.tet.2011.11.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conditions have been developed for the regioselective synthesis of 4-substituted isoxazoles from terminal alkynes and 3,4-disubstituted isoxazoles from internal alkynes. The methodology involves a one-pot titanium-catalyzed multicomponent coupling reaction followed by simple hydroxylamine hydrochloride addition. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：807 / 812

页数：6

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