Therapeutic Effects of Resveratrol in a Mouse Model of LPS and Cigarette Smoke-Induced COPD

被引：52

作者：

Chen, Jinlong ^{[1
]}

Yang, Xu ^{[2
]}

Zhang, Weiya ^{[1
]}

Peng, Danhua ^{[1
]}

Xia, Yanan ^{[1
]}

Lu, Yi ^{[1
]}

Han, Xiaodong ^{[3
]}

Song, Guangjie ^{[4
]}

Zhu, Jing ^{[1
]}

Liu, Renping ^{[1
]}

机构：

[1] Nanchang Univ, Sch Resources Environm & Chem Engn, Nanchang 330031, Peoples R China

[2] Nanchang Univ, Coll Med, Med Expt Educ Dept, Nanchang 330031, Peoples R China

[3] Wenzhou Cent Hosp, Dept Anesthesia, Wenzhou 325000, Peoples R China

[4] Xiangyang Cent Hosp, Dept Neurol, Xiangyang 441000, Peoples R China

来源：

INFLAMMATION | 2016年 / 39卷 / 06期

关键词：

COPD; resveratrol; beclin1; mucus hypersecretion; OBSTRUCTIVE PULMONARY-DISEASE; AIRWAY INFLAMMATION; TNF-ALPHA; TGF-BETA; ASTHMA; LUNG; EXPRESSION; IL-17; NEUTROPHILS; AUTOPHAGY;

D O I：

10.1007/s10753-016-0430-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This study was designed to examine whether resveratrol exerts the protective effects on LPS and cigarette smoke (LC)-induced COPD in a murine model. In lung histopathological studies, H&E, Masson's trichrome, and AB-PAS staining were performed. The cytokines (IL-6, IL-17, TGF-beta, and TNF-alpha) and inflammatory cells in BALF were determined. The Beclin1 level in the lungs of mouse was analyzed. Compared with the LC-induced mouse, the level of inflammatory cytokines (IL-17, IL-6, TNF-alpha, and TGF-beta) of the BALF in the resveratrol + cigarette smoke-treated mouse had obviously decreased. Histological examination of the lung tissue revealed that the resveratrol treatment attenuated the fibrotic response and mucus hypersecretion. In addition, resveratrol inhibited the expression of the Beclin1 protein in mouse lungs. The presented findings collectively suggest that resveratrol has a therapeutic effect on mouse LC-induced COPD, and its mechanism of action might be related to reducing the production of the Beclin1 protein.

引用

页码：1949 / 1959

页数：11

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