Novel Biomarkers in Cardiovascular Disease: Research Tools or Ready for Personalized Medicine?

被引：5
作者：
Stratz, Christian [1 ]
Amann, Michael [1 ]
Berg, David D. [2 ]
Morrow, David A. [2 ]
Neumann, Franz-Josef [1 ]
Hochholzer, Willibald [1 ,2 ]
机构：
[1] Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, TIMI Study Grp,Cardiovasc Div,Dept Med, Boston, MA 02115 USA
来源：
CARDIOLOGY IN REVIEW | 2012年 / 20卷 / 03期
关键词：
coronary heart disease; heart failure; therapy stratification; risk stratification; personalized medicine; GROWTH-DIFFERENTIATION FACTOR-15; C-REACTIVE PROTEIN; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; CARDIAC TROPONIN-T; TERMINAL PROVASOPRESSIN COPEPTIN; RISK STRATIFICATION; HEART-FAILURE; PROGNOSTIC VALUE; EARLY-DIAGNOSIS;
D O I：
10.1097/CRD.0b013e31824394e1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent years, a wide range of novel biomarkers have been evaluated for different cardiovascular disease states (eg, ischemia, congestion, and physiological stress), and many have shown promising results for the prediction of cardiovascular end points. However, to become useful for clinicians and to allow for personalized medicine, each novel biomarker must fulfill 3 fundamental criteria: (1) it must be easy to measure; (2) it must provide new information; and (3) it must help the clinician to manage patients. Although many biomarkers may be useful for prognostication, very few have been shown to improve the treatment of patients with cardiovascular disease when implemented in a clinical setting.
引用
收藏
页码：111 / 117
页数：7
相关论文
共 95 条
  • [1] GDF15, a cardioprotective TGF-β superfamily protein
    Ago, T
    Sadoshima, J
    [J]. CIRCULATION RESEARCH, 2006, 98 (03) : 294 - 297
  • [2] Association of Copeptin and N-Terminal proBNP Concentrations With Risk of Cardiovascular Death in Older Patients With Symptoms of Heart Failure
    Alehagen, Urban
    Dahlstroem, Ulf
    Rehfeld, Jens F.
    Goetze, Jens P.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (20): : 2088 - 2095
  • [3] Serial Measurement of Growth-Differentiation Factor-15 in Heart Failure Relation to Disease Severity and Prognosis in the Valsartan Heart Failure Trial
    Anand, Inder S.
    Kempf, Tibor
    Rector, Thomas S.
    Tapken, Heike
    Allhoff, Tim
    Jantzen, Franziska
    Kuskowski, Michael
    Cohn, Jay N.
    Drexler, Helmut
    Wollert, Kai C.
    [J]. CIRCULATION, 2010, 122 (14) : 1387 - +
  • [4] ACC/AHA 2007 Guidelines for the Management of Patients With unstable Angina/Non-ST-Elevation Myocardial Infarction A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine
    Anderson, Jeffrey L.
    Adams, Cynthia D.
    Antman, Elliott M.
    Bridges, Charles R.
    Califf, Robert M.
    Casey, Donald E., Jr.
    Chavey, William E.
    Fesmire, Francis M.
    Hochman, Judith S.
    Levin, Thomas N.
    Lincoff, A. Michael
    Peterson, Eric D.
    Theroux, Pierre
    Wenger, Nanette Kass
    Wright, R. Scott
    Smith, Sidney C.
    Jacobs, Alice K.
    Halperin, Jonathan L.
    Hunt, Sharon A.
    Krumholz, Harlan M.
    Kushner, Frederick G.
    Lytle, Bruce W.
    Nishimura, Rick
    Ornato, Joseph P.
    Page, Richard L.
    Riegel, Barbara
    [J]. CIRCULATION, 2007, 116 (07) : E148 - E304
  • [5] A New Season for Cardiac Troponin Assays: It's Time to Keep a Scorecard
    Apple, Fred S.
    [J]. CLINICAL CHEMISTRY, 2009, 55 (07) : 1303 - 1306
  • [6] Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome
    Apple, FS
    Wu, AHB
    Mair, J
    Ravkilde, J
    Panteghini, M
    Tate, J
    Pagani, F
    Christenson, RH
    Mockel, M
    Danne, O
    Jaffe, AS
    [J]. CLINICAL CHEMISTRY, 2005, 51 (05) : 810 - 824
  • [7] Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes
    Baldus, S
    Heeschen, C
    Meinertz, T
    Zeiher, AM
    Eiserich, JP
    Münzel, T
    Simoons, ML
    Hamm, CW
    [J]. CIRCULATION, 2003, 108 (12) : 1440 - 1445
  • [8] Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase
    Baldus, S
    Rudolph, V
    Roiss, M
    Ito, WD
    Rudolph, TK
    Eiserich, JP
    Sydow, K
    Lau, D
    Szöcs, K
    Klinke, A
    Kubala, L
    Berglund, L
    Schrepfer, S
    Deuse, T
    Haddad, M
    Risius, T
    Klemm, H
    Reichenspurner, HC
    Meinertz, T
    Heitzer, T
    [J]. CIRCULATION, 2006, 113 (15) : 1871 - 1878
  • [9] Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer
    Bauskin, Asne R.
    Brown, David A.
    Kuffner, Tamara
    Johnen, Heiko
    Luo, X. Wei
    Hunter, Mark
    Breit, Samuel N.
    [J]. CANCER RESEARCH, 2006, 66 (10) : 4983 - 4986
  • [10] Gender and renal function influence plasma levels of copeptin in healthy individuals
    Bhandari, Sanjay S.
    Loke, Ian
    Davies, Joan E.
    Squire, Ian B.
    Struck, Joachim
    Ng, Leong L.
    [J]. CLINICAL SCIENCE, 2009, 116 (3-4) : 257 - 263
12345678910