Non-Vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation

被引：9

作者：

Plitt, Anna ^{[1
]}

Ruff, Christian T. ^{[2
]}

Giugliano, Robert P. ^{[2
]}

机构：

[1] Mt Sinai Hosp, Dept Internal Med, One Gustave L Levy Pl, New York, NY 10029 USA

[2] Brigham & Womens Hosp, TIMI Study Grp, Div Cardiovasc, 350 Longwood Ave,1st Floor Off, Boston, MA 02115 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2016年 / 30卷 / 05期

关键词：

Atrial fibrillation; NOAC; Dabigatran; Rivaroxaban; Apixaban; Edoxaban; FACTOR XA INHIBITOR; DIRECT THROMBIN INHIBITOR; DABIGATRAN ETEXILATE; RENAL-FUNCTION; RISK-FACTORS; WARFARIN; RIVAROXABAN; REVERSAL; CARDIOVERSION; APIXABAN;

D O I：

10.1016/j.hoc.2016.05.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

For more than 50 years, vitamin K antagonists (VKAs) have been the standard of care for treatment of atrial fibrillation (AF). However, the numerous limitations of VKAs have led to the development of non-VKA oral anticoagulants (NOACs). There are 4 NOACs currently approved for prevention of thromboembolism in patients with nonvalvular AF. This article provides an overview of AF, summarizes basic properties of NOACs, and reviews the landmark trials. Current data on use of NOACs in special populations and specific clinical scenarios are also presented. Lastly, recommendations from experts on controversial topics of bleeding management and reversal are described.

引用

页码：1019 / +

页数：17

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