Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy

被引：230

作者：

Li, Hui ^{[1
]}

Kim, Yujun ^{[1
]}

Jung, Hyoje ^{[1
]}

Hyun, Ji Young ^{[2
]}

Shin, Injae ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Seoul 03722, South Korea

[2] Korea Res Inst Chem Technol KRICT, Data Convergence Drug Res Ctr, Dept Drug Discovery, Daejeon 34114, South Korea

来源：

CHEMICAL SOCIETY REVIEWS | 2022年 / 51卷 / 21期

基金：

新加坡国家研究基金会;

关键词：

AGGREGATION-INDUCED EMISSION; GAMMA-GLUTAMYL-TRANSPEPTIDASE; IN-VIVO; REACTIVE OXYGEN; LIVING CELLS; NITRIC-OXIDE; SELECTIVE DETECTION; LEUCINE AMINOPEPTIDASE; CANNABINOID RECEPTORS; ALKALINE-PHOSPHATASES;

D O I：

10.1039/d2cs00722c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Near-infrared (NIR) fluorophores have unique features that endow them with several advantages over conventional shorter wavelength emitting dyes. As a result, they have been widely utilized as fluorescence and photoacoustic imaging agents, as well as photodynamic and photothermal therapeutic agents. However, non-targeting NIR fluorescence-emitting organic molecules have the drawback of low selectivity toward tumors, which potentially results in severe side effects caused by damage to normal tissues. Thus, the development of NIR fluorophore-based substances that target tumors is a highly active area in medicinal chemistry research. Research efforts carried out thus far have led to the development of a number of NIR fluorophore-based, tumor imaging and therapeutic agents. The discussion in this review focuses on the results of research reported in the 2012-2021 period, giving particular emphasis to studies of NIR small organic dye-based imaging and therapeutic agents that are designed utilizing cancer-selective strategies.

引用

页码：8957 / 9008

页数：52

共 262 条

[21] Synthesis and Biological Evaluation of Low Molecular Weight Fluorescent Imaging Agents for the Prostate-Specific Membrane Antigen [J].