Low-density lipoproteins transport from blood flow to the arterial wall in the human carotid bifurcation

被引:0
作者
Amili, O [1 ]
Fatouraee, N [1 ]
机构
[1] Amirkabir Univ Technol, Tehran Polytech, Biomed Engn Fac, Biol Fluid Dynam Res Lab,Tehran Polytech, Tehran 15914, Iran
来源
PROCEEDINGS OF THE THIRD IASTED INTERNATIONAL CONFERENCE ON BIOMECHANICS | 2005年
关键词
atherosclerosis; concentration polarization; infiltration; and lipid transport;
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The carotid arteries are a common site of atherosclerotic plaque formation, which has been linked to the blood flow patterns and the mass transport phenomenon. The purpose of this research was to study the lipid transport in a human carotid artery model, focusing on the effects of local geometric and hemodynamic factors on mass transfer from blood flow to vessel wall and its concentration at the luminal surface of the artery. The Reynolds number, 250, and the Schmidt number, 6.66 x 10(5), were selected to model the mass transfer of LDL macro molecules, and in order to see the effect of Reynolds and Schmidt numbers to mass transport, the model was analyzed with different conditions. The steady state flow was used for two dimensional carotid geometry. At the inlet, the blood flow was assumed a steady fully developed laminar velocity profile with a uniform LDL concentration. The vessel wall was assumed permeable to water and semipermeable to LDL macro molecules. The problem was analyzed with the finite element method. The results show 26% increase of LDL concentration from inlet value at the luminal surface of the artery located in the separated flow region. The maximum value of LDL concentration occurred at the separation point.
引用
收藏
页码:139 / 144
页数:6
相关论文
共 12 条
  • [1] CHILDERS MA, 2001, ASME BIOENGINEERING, V50, P519
  • [2] Deng XY, 2004, PROCEEDINGS OF THE IASTED INTERNATIONAL CONFERENCE ON BIOMECHANICS, P94
  • [3] Computational Modeling of mass transfer and links to atherosclerosis
    Ethier, CR
    [J]. ANNALS OF BIOMEDICAL ENGINEERING, 2002, 30 (04) : 461 - 471
  • [4] Concentration polarization of low density lipoproteins (LDL) in the arterial system
    Fatouraee, N
    Deng, XY
    De Champlain, A
    Guidoin, R
    [J]. BIOTRANSPORT: HEAT AND MASS TRANSFER IN LIVING SYSTEMS, 1998, 858 : 137 - 146
  • [5] FATOURAEE N, 2004, P 28 CAN MED BIOL EN
  • [6] Mass transport in an anatomically realistic human right coronary artery
    Kaazempur-Mofrad, MR
    Ethier, CR
    [J]. ANNALS OF BIOMEDICAL ENGINEERING, 2001, 29 (02) : 121 - 127
  • [7] PULSATILE FLOW AND ATHEROSCLEROSIS IN THE HUMAN CAROTID BIFURCATION - POSITIVE CORRELATION BETWEEN PLAQUE LOCATION AND LOW AND OSCILLATING SHEAR-STRESS
    KU, DN
    GIDDENS, DP
    ZARINS, CK
    GLAGOV, S
    [J]. ARTERIOSCLEROSIS, 1985, 5 (03): : 293 - 302
  • [8] Analysis of hemodynamic fluid phase mass transport in a separated flow region
    Lutostansky, EM
    Karner, G
    Rappitsch, G
    Ku, DN
    Perktold, K
    [J]. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 2003, 125 (02): : 189 - 196
  • [9] PARKER PM, 2003, ATHEROSCLEROSIS
  • [10] Computational analysis of coupled blood-wall arterial LDL transport
    Stangeby, DK
    Ethier, CR
    [J]. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 2002, 124 (01): : 1 - 8