Sodium chloride affects Helicobacter pylori growth and gene expression

被引：61
作者：
Gancz, Hanan [1 ]
Jones, Kathleen R. [1 ]
Merrell, D. Scott [1 ]
机构：
[1] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA
来源：
JOURNAL OF BACTERIOLOGY | 2008年 / 190卷 / 11期
关键词：
D O I：
10.1128/JB.01728-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Epidemiological evidence links high-salt diets and Helicobacter pylori infection with increased risk of developing gastric maladies. The mechanism by which elevated sodium chloride content causes these manifestations is unclear. Here we characterize the response of H. pylori to temporal changes in sodium chloride concentration and show that growth, cell morphology, survival, and virulence factor expression are all altered by increased salt concentration.
引用
收藏
页码：4100 / 4105
页数：6
相关论文
共 33 条
  • [1] Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
    Alm, RA
    Ling, LSL
    Moir, DT
    King, BL
    Brown, ED
    Doig, PC
    Smith, DR
    Noonan, B
    Guild, BC
    deJonge, BL
    Carmel, G
    Tummino, PJ
    Caruso, A
    Uria-Nickelsen, M
    Mills, DM
    Ives, C
    Gibson, R
    Merberg, D
    Mills, SD
    Jiang, Q
    Taylor, DE
    Vovis, GF
    Trost, TJ
    [J]. NATURE, 1999, 397 (6715) : 176 - 180
  • [2] Helicobacter pylori infection and high dietary salt independently induce atrophic gastritis and intestinal metaplasia in commercially available outbred mongolian gerbils
    Bergin, IL
    Sheppard, BJ
    Fox, JG
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2003, 48 (03) : 475 - 485
  • [3] CARPENTER BM, 2007, APPL ENV MICROBI
  • [4] Bacterial factors that mediate colonization of the stomach and virulence of Helicobacter pylori
    Clyne, Marguerite
    Dolan, Brendan
    Reeves, Emer P.
    [J]. FEMS MICROBIOLOGY LETTERS, 2007, 268 (02) : 135 - 143
  • [5] MOLECULAR CHARACTERIZATION OF THE 128-KDA IMMUNODOMINANT ANTIGEN OF HELICOBACTER-PYLORI-ASSOCIATED WITH CYTOTOXICITY AND DUODENAL-ULCER
    COVACCI, A
    CENSINI, S
    BUGNOLI, M
    PETRACCA, R
    BURRONI, D
    MACCHIA, G
    MASSONE, A
    PAPINI, E
    XIANG, ZY
    FIGURA, N
    RAPPUOLI, R
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (12) : 5791 - 5795
  • [6] Flow cytometry and cell sorting of heterogeneous microbial populations: The importance of single-cell analyses
    Davey, HM
    Kell, DB
    [J]. MICROBIOLOGICAL REVIEWS, 1996, 60 (04) : 641 - +
  • [7] Localization of Helicobacter pylori urease and heat shock protein in human gastric biopsies
    Dunn, BE
    Vakil, NB
    Schneider, BG
    Miller, MM
    Zitzer, JB
    Peutz, T
    Phadnis, SH
    [J]. INFECTION AND IMMUNITY, 1997, 65 (04) : 1181 - 1188
  • [8] Fox JG, 1999, CANCER RES, V59, P4823
  • [9] Iron and pH homeostasis intersect at the level of fur regulation in the gastric pathogen Helicobacter pylori
    Gancz, H
    Censini, S
    Merrell, DS
    [J]. INFECTION AND IMMUNITY, 2006, 74 (01) : 602 - 614
  • [10] Exposure to salt and organic acids increases the ability of Listeria monocytogenes to invade Caco-2 cells but decreases its ability to survive gastric stress
    Garner, Matthew R.
    James, Karen E.
    Callahan, Michelle C.
    Wiedmann, Martin
    Boor, Kathryn J.
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (08) : 5384 - 5395
1234