Synthesis, characterization and antiprotozoal studies of some metal complexes of antimalarial drugs

被引：26

作者：

Ajibade, Peter A. ^{[1
]}

Kolawole, Gabriel A. ^{[2
]}

机构：

[1] Univ Ft Hare, Dept Chem, ZA-5700 Alice, South Africa

[2] Univ Zululand, Dept Chem, ZA-3886 Kwa Dlangezwa, South Africa

来源：

TRANSITION METAL CHEMISTRY | 2008年 / 33卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1007/s11243-008-9070-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Metal complexes of the antimalarials trimethoprim (TMP), chloroquine (CQ), and pyrimethamine (pyrm) formulated as [Mn(TMP)Cl-2(CH3OH)], [Co(TMP)(2)Cl-2(CH3OH)], [Pt(CQ)(2)Cl-2] and [Cu(pyrm)(2)(CH3COO)(2)] have been synthesized and characterized by elemental analysis, magnetic susceptibility measurements, IR and UV-Vis spectroscopy. The IR and electronic spectra are consistent with the proposed geometry for the complexes. The Mn(II) and Pt(II) complexes are four coordinate while the Cu(II) and Co(II) have octahedral geometry. The complexes were tested for in vitro activity against cultures of Trypanosoma cruzi, L. donovani, T. b. rhodesiense and the resistant strains of Plasmodium falciparum to determine their antiprotozoal activities and for their cytotoxicity with L-6 cells. The Pt(II) complex of chloroquine showed enhanced activity against the resistant strain of Plasmodium falciparum.

引用

页码：493 / 497

页数：5

共 39 条

[1] METAL-COMPOUNDS IN THERAPY AND DIAGNOSIS [J].

ABRAMS, MJ ;

MURRER, BA .

SCIENCE, 1993, 261 (5122) :725-730

[2] Trypanosoma brucei genomics and the challenge of identifying drug and vaccine targets [J].

Agbo, EC ;

Majiwa, PAO ;

Büscher, P ;

Claassen, E ;

Pas, MFWT .

TRENDS IN MICROBIOLOGY, 2003, 11 (07) :322-329

[3] Synthesis and characterization of Ni(II), Pd(II) and Pt(II) complexes of 2,4-diamino-5-(3, 4, 5-trimethoxybenzyl) pyrimidine complexes [J].

Ajibade, P. A. ;

Kolawole, G. A. ;

O'Brien, P. ;

Helliwell, M. .

JOURNAL OF COORDINATION CHEMISTRY, 2006, 59 (14) :1621-1628

[4] Metal complexes of 4-amino-N-(2-pyrimidinyl)benzene sulfonamide: Synthesis, characterization and Antiprotozoal studies [J].

Ajibade, Peter A. ;

Kolawole, Gabriel A. ;

O'Brien, Paul .

SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY, 2007, 37 (08) :653-659

[5] Cobalt(II) complexes of the antibiotic sulfadiazine, the X-ray single crystal structure of [Co(C10H9N4O2S)2(CH3OH)2] [J].

Ajibade, Peter A. ;

Kolawole, Gabriel A. ;

O'Brien, Paul ;

Helliwell, Madeleine ;

Raftery, James .

INORGANICA CHIMICA ACTA, 2006, 359 (10) :3111-3116

[6]

BALTER M, 2000, SCIENCE, V290, P428

[7] The trypanosomiases [J].

Barrett, MP ;

Burchmore, RJS ;

Stich, A ;

Lazzari, JO ;

Frasch, AC ;

Cazzulo, JJ ;

Krishna, S .

LANCET, 2003, 362 (9394) :1469-1480

[8]

Breman JG, 2001, AM J TROP MED HYG, V64, P1

[9] Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense:: a randomised trial [J].

Burri, C ;

Nkunhu, S ;

Merolle, A ;

Smith, T ;

Blum, J ;

Brun, R .

LANCET, 2000, 355 (9213) :1419-1425

[10]

Cotton FA, 1980, ADV INORGANIC CHEM

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