[1] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 300, Taiwan
[2] MacKay Mem Hosp, Div Genet, Dept Obstet & Gynecol, Taipei 104, Taiwan
[3] Food Ind Res & Dev Inst, Bioresource Collect & Res Ctr, Hsinchu 300, Taiwan
[4] Natl Hlth Res Inst, Div Mol & Genom Med, Miaoli 350, Taiwan