Recent progress in design and preparation of glucose-responsive insulin delivery systems

被引：90

作者：

Shen, Di ^{[1
]}

Yu, Haojie ^{[1
]}

Wang, Li ^{[1
]}

Khan, Amin ^{[1
]}

Haq, Fazal ^{[1
]}

Chen, Xiang ^{[1
]}

Huang, Qiao ^{[1
]}

Teng, Lisong ^{[2
]}

机构：

[1] Zhejiang Univ, State Key Lab Chem Engn, Coll Chem & Biol Engn, Hangzhou 310027, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Oncol Surg & Canc Ctr, Hangzhou 310003, Zhejiang, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2020年 / 321卷

关键词：

Glucose-responsive compounds; Controlling release; Insulin delivery; MESOPOROUS SILICA NANOPARTICLES; BORONATE AFFINITY-CHROMATOGRAPHY; HAMMETT SUBSTITUENT CONSTANTS; ORAL DELIVERY; CONTROLLED-RELEASE; DIABETES-MELLITUS; CONCANAVALIN-A; PHENYLBORONIC ACID; SENSITIVE VESICLES; ASPERGILLUS-NIGER;

D O I：

10.1016/j.jconrel.2020.02.014

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Diabetes, as a global threat nowadays, causes the wide usage of exogenous insulin. Subcutaneous injection is the traditional insulin administration in the diabetes treatments and is inconvenient and painful, which results in potential side effects of hypoglycemia. Scientists have made great efforts to develop alternatives. As the promising solutions, smart insulin delivery systems fabricated with glucose- responsive compounds attract considerable attention in the field of diabetes treatments. This review discusses the classifications, properties, response mechanisms of the glucose-responsive compounds, glucose oxidase and concanavalin A and recent progress of glucose-responsive insulin delivery systems.

引用

页码：236 / 258

页数：23

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