Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells

被引：24

作者：

Shen, Haifa ^{[1
,2
]}

Sun, Tong ^{[1
]}

Hoang, Hanh H. ^{[1
]}

Burchfield, Jana S. ^{[1
]}

Hamilton, Gillian F. ^{[1
]}

Mittendorf, Elizabeth A. ^{[3
]}

Ferrari, Mauro ^{[1
,4
]}

机构：

[1] Houston Methodist Res Inst, 6670 Bertner Ave,MS R12-219, Houston, TX 77030 USA

[2] Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY 10065 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Breast Surg Oncol, Houston, TX 77030 USA

[4] Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA

来源：

SEMINARS IN IMMUNOLOGY | 2017年 / 34卷 / 0C期

基金：

美国国家卫生研究院;

关键词：

Nanotechnology; Cancer immunotherapy; Tumor-infiltrating lymphocytes; Tumor microenvironment; REGULATORY T-CELLS; ANTIGEN RECEPTOR IMMUNOTHERAPY; DENDRITIC CELLS; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE; BREAST-CANCER; LYMPH-NODES; EXTRACELLULAR-MATRIX; ANTITUMOR IMMUNITY; RNA DELIVERY;

D O I：

10.1016/j.smim.2017.09.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cancer immunotherapy has become arguably the most promising advancement in cancer research and therapy in recent years. The efficacy of cancer immunotherapy is critically dependent on specific physiological and physical processes - collectively referred to as transport barriers - including the activation of T cells by antigen presenting cells, T cells migration to and penetration into the tumor microenvironment, and movement of nutrients and other immune cells through the tumor microenvironment. Nanotechnology-based approaches have great potential to help overcome these transport barriers. In this review, we discuss the ways that nanotechnology is being leveraged to improve the efficacy and potency of various cancer immunotherapies.

引用

页码：114 / 122

页数：9

共 123 条

[1] Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma [J].

Ahmed, Nabil ;

Brawley, Vita S. ;

Hegde, Meenakshi ;

Robertson, Catherine ;

Ghazi, Alexia ;

Gerken, Claudia ;

Liu, Enli ;

Dakhova, Olga ;

Ashoori, Aidin ;

Corder, Amanda ;

Gray, Tara ;

Wu, Meng-Fen ;

Liu, Hao ;

Hicks, John ;

Rainusso, Nino ;

Dotti, Gianpietro ;

Mei, Zhuyong ;

Grilley, Bambi ;

Gee, Adrian ;

Rooney, Cliona M. ;

Brenner, Malcolm K. ;

Heslop, Helen E. ;

Wels, Winfried S. ;

Wang, Lisa L. ;

Anderson, Peter ;

Gottschalk, Stephen .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15) :1688-+

[2] Cell-mediated delivery of nanoparticles: Taking advantage of circulatory cells to target nanoparticles [J].

Anselmo, Aaron C. ;

Mitragotri, Samir .

JOURNAL OF CONTROLLED RELEASE, 2014, 190 :531-541

[3] Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity [J].

Ban, Yi ;

Mai, Junhua ;

Li, Xin ;

Mitchell-Flack, Marisa ;

Zhang, Tuo ;

Zhang, Lixing ;

Chouchane, Lotfi ;

Ferrari, Mauro ;

Shen, Haifa ;

Ma, Xiaojing .

CANCER RESEARCH, 2017, 77 (11) :2857-2868

[4] Chimeric Antigen Receptor Therapy for Cancer [J].

Barrett, David M. ;

Singh, Nathan ;

Porter, David L. ;

Grupp, Stephan A. ;

June, Carl H. .

ANNUAL REVIEW OF MEDICINE, VOL 65, 2014, 65 :333-347

[5] Principles of nanoparticle design for overcoming biological barriers to drug delivery [J].

Blanco, Elvin ;

Shen, Haifa ;

Ferrari, Mauro .

NATURE BIOTECHNOLOGY, 2015, 33 (09) :941-951

[6] T-cell activation by dendritic cells in the lymph node: lessons from the movies [J].

Bousso, Philippe .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (09) :675-684

[7] Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class [J].

Brischwein, Klaus ;

Parr, Larissa ;

Pflanz, Stefan ;

Volkland, Jorg ;

Lumsden, John ;

Klinger, Matthias ;

Locher, Mathias ;

Hammond, Scott A. ;

Kiener, Peter ;

Kufer, Peter ;

Schlereth, Bernd ;

Baeuerle, Patrick A. .

JOURNAL OF IMMUNOTHERAPY, 2007, 30 (08) :798-807

[8] A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells [J].

Carreno, Beatriz M. ;

Magrini, Vincent ;

Becker-Hapak, Michelle ;

Kaabinejadian, Saghar ;

Hundal, Jasreet ;

Petti, Allegra A. ;

Ly, Amy ;

Lie, Wen-Rong ;

Hildebrand, William H. ;

Mardis, Elaine R. ;

Linette, Gerald P. .

SCIENCE, 2015, 348 (6236) :803-808

[9] Elements of cancer immunity and the cancer-immune set point [J].

Chen, Daniel S. ;

Mellman, Ira .

NATURE, 2017, 541 (7637) :321-330

[10] Oncology Meets Immunology: The Cancer-Immunity Cycle [J].

Chen, Daniel S. ;

Mellman, Ira .

IMMUNITY, 2013, 39 (01) :1-10

← 1 2 3 4 5 6 7 8 9 10 →